Specifications
- Druh protilátky:Primární
- Název antigenu:Presenilin 1
- Symbol antigenu:PSEN1
- Klonovalita:Polyclonal
- Spojení:Alexa Fluor® 488
- Hostitel:Rabbit
- Imunochemie:Yes
- Izotyp:IgG
- Reaktivita:Human,Rat,Mouse
- Křížová adsorbce:No
- Formulář:liquid
- Identifikační číslo genu:5663
- Synonyma antigenu:FAD|Alzheimer Disease 3|Homo Sapiens Clone CC44 Senilin 1|Senilin 1|PS1|PSNL1|AD3|S182 Protein
- Skladovací pufr:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Skladovací teplota:Store at 4°C for 12 months
- Koncentrace:1 μg/μl
- Transportní teplota:4°C
- Čištění:Purified by Protein A
- Bal.:100 µl
Specifications
About this item
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: PSEN1
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 488
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat