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- 抗体类型:Primary
- 抗原:CD257
- 克隆形成能力:Monoclonal
- 克隆:1D6
- 结合:APC (Allophycocyanin)
- 流式细胞计:Yes
- 主机:Mouse
- 同位型:IgG1 kappa
- 反应性:Human
- 形式:Liquid
- 基因:10673
- 抗原同义词:member 13b|TNF and ApoL-related leukocyte expressed ligand 1|ZTNF4|dendritic cell-derived TNF-like molecule|THANK|Delta4 BAFF|tumor necrosis factor (ligand) superfamily member 13b|TALL-1|member 20|delta BAFF|tumor necrosis factor ligand 7A|tumor necrosis factor (ligand) superfamily|B-lymphocyte stimulator|TNF homolog that activates apoptosis|TNFSF20|ApoL related ligand TALL-1|DTL|B-cell-activating factor|TNFSF13B|TALL1|BLYS|tumor necrosis factor-like protein ZTNF4
- 存储缓冲:PBS, 0.2% BSA, 0.1% gelatin, 0.09% sodium azide, pH 7.2
- 存储温度:4° C, store in dark, DO NOT FREEZE!
- 浓度:5 µl/Test
- 净化:Affinity chromatography
- 抗体大小:100 Tests
- 包装规格:100 Tests
Description: The 1D6 monoclonal antibody reacts with human BLyS (B lymphocyte stimulator), also known as BAFF (B cell activating factor from the TNF family), TALL-1 (TNF and apoptosis leukocyte-expressed ligand-1), THANK (TNF homologue that activates apoptosis, nuclear factor KappaB and c-Jun NH2-terminal kinase) and zTNF4. BLyS, a member of the TNF family, is a type II membrane protein that exists in both membrane-bound and soluble forms. Expression of membrane-bound BLyS on monocytes lineage is regulated by IFN gamma. BLyS acts as a potent B cell growth factor and costimulator of Ig production. BLyS transgenic mice develop severe B cell hyperplasia and autoimmune lupus-like disease characterized by the presence of autoantibodies against nuclear antigens and immune complexes deposited in the kidney. Data from animal models imply a role for BLyS in human autoimmune diseases. To date BCMA, TACI and BR3 have been identified as receptors for BLyS. APRIL, another TNF family member, and BLyS can form active heterotrimeric molecules when coexpressed and these circulating heterotrimers are present in serum samples from patients with systemic immune-based rheumatic diseases. Furthermore, it has been reported that BLyS and APRIL, share BCMA and TACI as their receptors. Applications Reported: This 1D6 antibody has been reported for use in flow cytometric analysis. Applications Tested: This 1D6 antibody has been pre-titrated and tested by flow cytometric analysis of human BLyS transfected cells. This can be used at 5 µL (0.25 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser BAFF is a membrane bound cytokine expressed by B cell lineage cells. The soluble form of the cytokine binds to the receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. BAFF is a potent B cell activator, and important for the proliferation and differentiation of B cells. BAFF is also expressed by T lymphocytes and has been shown to promote T cell activation and survival. Isoforms representing alternatively spliced, and glycosylated variants have been identified.
Flow Cytometry: 5 µL (0.25 µg)/test
Type: Primary
Antigen: CD257
Clonality: Monoclonal
Clone: 1D6
Conjugation: APC (Allophycocyanin)
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human