These protein-based columns are suitable for separation of basic, acidic and non-protolytic compounds. These columns function entirely in the reversed phase chromatographic mode, using buffers with low organic modifier content and at moderate pH values.
- Extremely broad applicability for separation of chiral drugs
- Possibility to dynamically improve enantioseparation
- Separates enantiomers of an extremely broad range of drug compounds such as amines, acids and non protolytes
CHIRALPAK® AGP is the second generation chiral separation column based on the use of α1-acid glycoprotein (AGP) as the CSP. Through a patented process, α1-AGP has been immobilised on porous, spherical silica particles (5 μm). The surface chemistry of the silica proves a stable chiral separation material with extremely broad applicability.
Racemic amines, acids and non protolytic compounds can be resolved directly, without derivatisation. The column enables resolution of a very large number of chiral compounds from different compound classes. This is due to the unique nature of the CSP, and the fact that enantioselectivity can be induced by choosing a proper mobile phase composition.