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2189 results for "TMC HALLCREST"

2189 Risultati per: "TMC HALLCREST"

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Garcinol ≥95% (by TLC)

Supplier: ENZO LIFE SCIENCES

HAT inhibitor

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Anandamide ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Endogenous [1] ligand for the CB1 receptor (CB1: Ki=52nm; CB2: Ki=1930nm [2]) and TRPV1 (Ki=5.78µM [3,4]). Inhibits NF-κB activation through direct binding to IKKβ [5] and induces apoptosis independently of cannabinoid or vanilloid receptors [6]. Activates the MAP kinase (MAPK/ERK) signalling pathway [7].

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Apigenin ≥97% (by TLC)

Supplier: ENZO LIFE SCIENCES

Antioxidant and chemopreventive

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Milrinone ≥97% (by TLC)

Supplier: ENZO LIFE SCIENCES

PDE3 inhibitor

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Calpeptin ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Calpain and cathepsin inhibitor

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L-744,832 ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Ras farnesyltransferase inhibitor. Induces tumor regression in transgenic mice with multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Induces p21 expression and arrests cells at G1. Causes enhanced mitotic sensitivity to taxol.

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BMOV ≥96% (by TLC)

BMOV ≥96% (by TLC)

Supplier: ENZO LIFE SCIENCES

Organic vanadium complex which acts as a potent insulin mimic.

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Latrunculin A ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Ultra-pure; inhibits actin polymerization

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Capsaicin ≥99% (by TLC)

Supplier: ENZO LIFE SCIENCES

TRPV1 agonist

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Ilimaquinone ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

ADP-ribosylation factor inhibitor

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Palmitoylethanolamide ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Endogenous cannabinoid. Weak ligand of CB1 (Ki=23.8µM) and CB2 (Ki=13.9µM) receptor. Inhibits fatty acid amide hydrolase (FAAH) (IC50=5.1µM). Immunosuppressant, anti-inflammatory, anti-nociceptive and anti-convulsant in vivo. The exact mode of action has not yet been revealed. It has been suggested that PEA: i) binds to a yet to be discovered cannabinoid receptor similar to CB2; ii) administered in vivo elicits the synthesis of endogenous agonists of CB2; iii) acts as an "entourage" compound by enhancing the activity and/or by influencing the turnover of endogenous agonists of CB2, possibly but not uniquely, by inhibiting their degradation.

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Virodhamine ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Cannabinoid receptor ligand.

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DMOG ≥99% (by TLC)

Supplier: ENZO LIFE SCIENCES

DMOG is a cell permeable prolyl-4-hydroxylase inhibitor which upregulates HIF activity. HIF activation stimulates angiogenesis in several different models. DMOG also inhibits FIH (Factor Inhibiting HIF), an asparaginyl hydroxylase, which enhances the HIF response. It is active in vivo and attenuates myocardial injury in a rabbit ischemia reperfusion model (20mg/kg). Is expected to act pro-angiogenic.

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Cerulenin ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Fatty acid synthase inhibitor

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Methanandamide ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Cannabinoid receptor ligand

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GW5074 ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Potent and selective cell permeable inhibitor of cRAF1 kinase (IC50 = 9 nM) with 100-fold selectivity over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. A useful tool for assessing the involvement of the Ras/Raf-1/ERK pathway in various signaling pathways. Displays neuroprotective effects in vivo through a MEK-ERK and Akt-independent mechanism.

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Arachidonoyl-AMC ≥99%

Arachidonoyl-AMC ≥99%

Supplier: ENZO LIFE SCIENCES

FAAH substrate.

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Mirin ≥95% (by TLC)

Supplier: ENZO LIFE SCIENCES

MRN inhibitor

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FCCP ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

MPTP inhibitor

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ML-9 ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Selective inhibitor of MLC kinase (Ki=3.8 µM). Inhibits insulin-stimulated 2-deoxyglucose transport and PP-1 activation in adipocytes, possibly via an effect on MAP kinase or its activation. Useful PKB inhibitor (IC50=10-50 µM). Also known to inhibit PKA (IC50=20 µM) and S6 kinase (IC50=50 µM). Does not inhibit PI 3-kinase.

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Cilostamide ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

PDE inhibitor

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PP2 ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Src kinase inhibitor

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Acitretin ≥98% (by TLC)

Acitretin ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Retinoic acid receptor ligand.

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L-NASPA ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

L-NASPA is an antagonist of LPA-induced platelet aggregation and chloride conductance in Xenopus oocytes. In human breast carcinoma MDA-MB231 cells it is a potent LPA agonist.

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Ac-WEHD-AMC

Supplier: ENZO LIFE SCIENCES

Substrate for caspase-1 and -5

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Cantharidin ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

PP2A inhibitor

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Aphidicolin ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Reversible inhibitor of DNA polymerase a and d

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TOFA ≥99% (by TLC)

Supplier: ENZO LIFE SCIENCES

Acetyl-CoA inhibitor

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SB202190 ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Cell permeable, potent and selective p38 MAP kinase inhibitor (IC50=30 nM). Inhibits p38α and ß, but not γ and δ isoforms. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators. A useful tool for dissecting the role of p38 in signaling pathways. Induces apoptosis.

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KT5823 ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

PKG inhibitor

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