5331 Risultati per: "IKA"

Supplier: ANTIBODIES.COM

Mouse monoclonal [IGA/764] antibody to CD79a for Flow Cytometry, IF, WB and IHC-P with samples derived from human.

Supplier: ANTIBODIES.COM

Mouse monoclonal [IGA/764] antibody to CD79a for Flow Cytometry, IF, WB and IHC-P with samples derived from Human.

Supplier: ANTIBODIES.COM

Goat anti-chicken IgA heavy chain secondary antibody for WB, IHC, ICC and ELISA with samples derived from chicken.

Supplier: ANTIBODIES.COM

Goat anti-mouse IgA heavy chain secondary antibody for WB, IHC, ICC and ELISA with samples derived from mouse.

Supplier: ANTIBODIES.COM

Goat anti-dog IgA heavy chain secondary antibody for WB, IHC, ICC and ELISA with samples derived from dog.

Supplier: OriGene

Anti-CHUK Rabbit Polyclonal Antibody

Supplier: Biorbyt

Anti-IgA/IgG/IgM Goat Polyclonal Antibody (Biotin)

Supplier: Biorbyt

Anti-IgA Goat Polyclonal Antibody (HRP (Horseradish Peroxidase))

Supplier: Biorbyt

Anti-IgA Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Supplier: Biorbyt

Anti-IgA Goat Polyclonal Antibody (TRITC (Tetramethylrhodamine Isothiocyanate))

Supplier: Biorbyt

Anti-IgA Rabbit Polyclonal Antibody (TRITC (Tetramethylrhodamine Isothiocyanate))

Supplier: Biorbyt

Anti-IgA/IgG1/IgG2/IgM Rabbit Polyclonal Antibody

Supplier: Biorbyt

Anti-IgA Goat Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Supplier: Biorbyt

Anti-IgA Goat Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Supplier: Biorbyt

Anti-IgA Goat Polyclonal Antibody (TRITC (Tetramethylrhodamine Isothiocyanate))

Supplier: Biorbyt

Anti-IgA/IgG/IgM Goat Polyclonal Antibody (Biotin)

Supplier: ProSci Inc.

A disulphide-linked heterodimer, consisting of mb-1 (or CD79a) and B29 (or CD79b) polypeptides, is non-covalently associated with membrane-bound immunoglobulins on B cells. This complex of mb-1 and B29 polypeptides and immunoglobulin constitute the B cell Ag receptor. CD79a first appears at pre B cell stage, early in maturation, and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas. It is not present in myeloid or T cell lines. Anti-CD79a is generally used to complement anti-CD20 especially for mature B-cell lymphomas after treatment with Rituximab (anti-CD20). This antibody will stain many of the same lymphomas as anti-CD20, but also is more likely to stain B-lymphoblastic lymphoma/leukemia than is anti-CD20. Anti-CD79a also stains more cases of plasma cell myeloma and occasionally some types of endothelial cells as well.

Supplier: ANTIBODIES.COM

Goat anti-human IgA heavy chain secondary antibody for WB, IHC, ICC and ELISA with samples derived from human.

Supplier: ANTIBODIES.COM

Mouse monoclonal [IGA/1406] antibody to CD79a for Flow Cytometry, IF and WB with samples derived from Human.

Supplier: ANTIBODIES.COM

Rabbit polyclonal antibody to non-muscle Myosin IIA for WB and IHC with samples derived from human, mouse and rat.

Supplier: ANTIBODIES.COM

Rabbit polyclonal antibody to ACTR-IIA for WB and ELISA with samples derived from Human, Mouse and Rat.

Supplier: Bioss

Nuclear factor kappa B (NFkB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NFkB mediates the expression of a great variety of genes in response to extracellular stimuli including IL1, TNF alpha, and bacterial product LPS. NFkB is associated with IkB proteins in the cell cytoplasm, which inhibit NFkB activity. IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKK alpha and IKK beta). IKK alpha and IKK beta interact with each other and both are essential for NFkB activation. IKK alpha specifically phosphorylates IkBa. IKKa is expressed in variety of human tissues.

Supplier: Abcam

Alkaline Phosphatase Rabbit monoclonal [EPR6043] to IKK beta.

Supplier: Abcam

Alexa Fluor® 488 Rabbit monoclonal [EPR5367-76] to IgA.

Supplier: Abcam

Rabbit monoclonal [EP2606Y] to PKA alpha/beta/gamma (catalytic subunit) (phospho T197).

Supplier: Bioss

Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilising MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities. Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP. Additionally, phosphorylates the CREBBP-interacting protein NCOA3.

Supplier: US Biological

Anti-Myosin IIA, non-muscle, heavy chain Human Monoclonal Antibody [clone: SF9]

Supplier: Bioss

Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilising MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities. Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP. Additionally, phosphorylates the CREBBP-interacting protein NCOA3.

Supplier: Bioss

Nuclear factor kappa B (NFkB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NFkB mediates the expression of a great variety of genes in response to extracellular stimuli including IL1, TNF alpha, and bacterial product LPS. NFkB is associated with IkB proteins in the cell cytoplasm, which inhibit NFkB activity. IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKK alpha and IKK beta). IKK alpha and IKK beta interact with each other and both are essential for NFkB activation. IKK alpha specifically phosphorylates IkBa. IKKa is expressed in variety of human tissues.

Supplier: Biorbyt

Anti-IgA/IgG1/IgG2a/IgG2b/IgG2c/IgM Polyclonal Antibody