"Enzo Life Sciences"

Supplier: Enzo Life Sciences

Recommended Applications: Flow Cytometry, IF, IHC (FS)

Species reactivity: Human, Dog

Supplier: Enzo Life Sciences

The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

Supplier: Enzo Life Sciences

mTOR (FKBP12-rapamycin associated protein (FRAP)) is one of a family of proteins involved in cell cycle progression, DNA recombination, and DNA damage detection. It has been shown to associate with the immunophilin FKBP12 in a rapamycin-dependent fashion. FKBP12-rapamycin-binding (FRB) domain is a conserved 11kDa region necessary for FKBP12-rapamycin binding. FRB is one of several functional domains of mTOR: HEAT (Huntington elongation factor 1A-protein phosphatase 2A-A subunit-TOR); FAT (FRAP, ATM, TTRAP2); PIKK (PI3-kinase-related kinase); RD (regulatory domain); and FATC (FAT, C terminal).

Supplier: Enzo Life Sciences

Histamine H₁ receptor antagonist. An antagonist of low affinity neurotensin receptors.

Supplier: Enzo Life Sciences

Produced in E. coli. Non-glycosylated protein, containing 147 amino acids.

Supplier: Enzo Life Sciences

For the quantitative determination of urinary prostacyclin metabolites in culture supernatants and urine from any species.

Supplier: Enzo Life Sciences

FLUOR DE LYS® deacetylated standard, 10 mm, in DMSO, FLUOR DE LYS®

Supplier: Enzo Life Sciences

First-to-market 15-d-PGJ2 ELISA commercially available for eicosanoid research.

Supplier: Enzo Life Sciences

Activator of MAPK, Jnk and p38

Supplier: Enzo Life Sciences

Bax is an appromimately 22 kDa pro-apoptotic protein belonging to the Bcl-2 family of proteins, which are characterised by the presence of atleast one Bcl-2 homology (BH) domains.

Supplier: Enzo Life Sciences

Inhibits thromboxane production in human platelets

Supplier: Enzo Life Sciences

Potent and selective phosphoinositide 3-kinase (PI(3)K) p110γ inhibitor shown to be selective for class IB PI(3)K-mediated cellular effects.

Supplier: Enzo Life Sciences

A QuantiZyme™ Assay System. The MMP-9 Colorimetric Drug Discovery Kit is a complete assay system designed to screen inhibitors of matrix metalloproteinase-9 (MMP-9, gelatinase B) using a thiopeptide as a chromogenic substrate.

Supplier: Enzo Life Sciences

Genistein

Supplier: Enzo Life Sciences

Cell-permeable, potent and AMP-competitive inhibitor of glycogen phosphorylase.

Supplier: Enzo Life Sciences

Acetylation and methylation of lysine are important post-translational modifications that regulate numerous protein-protein and protein-DNA interactions. Lysine acetylation and methylation involves the transfer of acetylCoA, or one or more methyl groups, to the e-amino group of lysine by modifying enzymes and cofactors. Histones and transcription factors are the primary targets of lysine acetylation and methylation, with either modification capable of inducing gene silencing or expression due to differential regulation of cofactors. For example, varying degrees of mono-, di-, and tri-methylation or acetylation of histone H3 at lysine residue 9 are known to demark distinct chromatin regions during various states of gene activation (methylation) or repression (acetylation).