JK 184 ≥99% Hedgehog signaling inhibitor

Potent Hedgehog (Hh) signaling inhibitor. Inhibits alcohol dehydrogenase 7 (Adh7) (IC₅₀ = 210 nM) and prevents Gli-dependent transcriptional activity (IC₅₀ = 30 nM). Potently inhibits microtubule assembly. Additionally displays antitumor activity.

 : All products are FOR RESEARCH USE ONLY. PRODUCTS ARE NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. Customer is granted a limited use non-exclusive licence for its own internal research. Any control manufacturer supplies with a Product is limited to use only to validate the relevant Product. By using the Product, Customers agree not to attempt to reverse engineer or otherwise perform any compositional, structural, functional or other analyses directed to learning the methodology, formulae, sequences, processes, make-up or production of any of the Products or portions thereof.