Human Recombinant IL-10 (CTGrade GMP) (from E. coli)

Supplier: Shenandoah Biotechnology

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Supplier: Shenandoah Biotechnology

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About this item

IL-10 is an anti-inflammatory cytokine produced by macrophages and type 2 T helper (Th2) cells.

High quality
Low endotoxin
Lot-to-lot consistency
Animal free
Manufactured following GMP guidelines

Inhibits the production of pro-inflammatory cytokines such as interferon gamma (IFNγ), tumor necrosis factor alpha (TNFα), interleukin 2 (IL-2), interleukin 3 (IL-3), interleukin 4 (IL-4), and granulocyte-macrophage colony-stimulating factor (GM-CSF), made by macrophages and regulatory T cells
Suppresses antigen presentation on antigen presenting cells, and enhances the survival, proliferation, and antibody production of B cells
The biological activity of CTGrade GMP interleukins and growth factors is standardised, where applicable, to WHO International standards, providing cell and gene therapy developers consistent, lot-to-lot biological activity and performance

Host Cell Protein: ≤30 ng/ml
Host Cell DNA: ≤0,01 ng/ml
Sterility testing: No Growth
Mycoplasma: Negative

Caution: For research use or further manufacturing only.

Specifications

Coniugazione:
Non coniugato
Protein function:
Cytokine
Protein/peptide type:
Recombinant
Sorgente luminosa:
E. coli
Specie:
Human
Condizioni di conservazione:
At or below –20 °C
Contenuto di endotossine:
Endotoxin LAL (EU/µg) ≤0,05
Attività biologica:
Bioactivity Assay: Proliferation of MC/9, ED₅₀ ≤5 ng/ml, Bioactivity ≥5,0×10³ IU/µg
ID gene:
P22301
Ricostituzione:
Sterile water at 0,1 - 0,5 mg/ml
Privo di endotossine:
N
Senza corriere:
Y
Protease-free:
N
Senza animali:
Y
Protein synonyms:
B-TCGF|TGIF|CSIF
Protein/peptide name:
CTGrade GMP IL-10
Purezza:
≥97%
Peso molecolare:
18,8 kDa
Sequenza:
MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N
Livello di endotossine:
Low
Formulazione:
10 mM Sodium phosphate, pH 7,5
Esente da nucleasi:
N
Grado:
GMP
Temperatura di spedizione:
Ambient
Applicazioni testate:
Bioassay