Human Recombinant IL-4 (CTGrade GMP) (from E. coli)

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About this item

IL-4 is an immunomodulatory cytokine that stimulates B cell proliferation and activates eosinophils, basophils, and mast cells.

High quality
Low endotoxin
Lot-to-lot consistency
Animal free
Manufactured following GMP guidelines

Induces vascular cell adhesion molecule (VCAM)-1 expression on endothelial cells and involved in collagen production by fibroblasts
Plays a key role in promotion of Th2 differentiation from naive helper T cells
Defines the Th2 phenotype of lymphocytes
Regulates cell proliferation, apoptosis, and expression of numerous genes in various cell types
The biological activity of CTGrade GMP interleukins and growth factors is standardised, where applicable, to WHO International standards, providing cell and gene therapy developers consistent, lot-to-lot biological activity and performance

Host Cell Protein: ≤30 ng/ml
Host Cell DNA: ≤0,01 ng/ml
Sterility testing: No Growth
Mycoplasma: Negative

Caution: For research use or further manufacturing only.

Specifications

Coniugazione:
Non coniugato
Protein function:
Cytokine
Protein/peptide type:
Recombinant
Sorgente luminosa:
E. coli
Specie:
Human
Condizioni di conservazione:
At or below –20 °C
Contenuto di endotossine:
Endotoxin LAL (EU/µg) ≤0,05
Attività biologica:
Bioactivity Assay: TF-1 cell proliferation, ED₅₀ ≤0,25 ng/ml, Bioactivity ≥1,4x10⁴ IU/µg
ID gene:
P05112
Ricostituzione:
Sterile water at 0,1 - 0,5 mg/ml
Privo di endotossine:
N
Senza corriere:
Y
Protease-free:
N
Senza animali:
Y
Protein synonyms:
BCGF|B-cell stimulatory factor-1|BCDF|BSF-1
Protein/peptide name:
CTGrade GMP IL-4
Purezza:
≥98%
Peso molecolare:
15,1 kDa
Sequenza:
MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS
Livello di endotossine:
Low
Formulazione:
20 mM Sodium phosphate, pH 7,5
Esente da nucleasi:
N
Grado:
GMP
Temperatura di spedizione:
Ambient
Applicazioni testate:
Bioassay