Specifications
- Tipo anticorpo:Primary
- Tipo di anticorpi:CD22 molecule
- Simbolo dell'antigene:CD22
- Clonalità:Monoclonale
- Clone:FR10B4
- Coniugazione:Non coniugato
- Citometria a flusso:Yes
- Ospite:Mouse
- ImmunoFluorescenza:Yes
- Isotipo:IgG1 kappa
- Reattività:Human
- Neutralisation:Yes
- Formato:Purified Antibody
- Forma:Liquid
- ID gene:P20273
- Sinomini antigene:CD22
- Tampone di conservazione:PBS with 0,1 mg/ml BSA and 0,05% sodium azide
- Temperatura di conservazione:Aliquot and Store at 2…8 °C. Avoid freez-thaw cycles.
- Concentrazione:0,2 mg/ml
- Temperatura di spedizione:4 °C
- Immunogeno:Human Burkitt’s lymphoma cells were used as the immunogen for the CD22 antibody.
- Applicazioni testate:Functional
- Purificazione:Protein G affinity chromatography
- Taglia:100 µg
- Conf:100 µG
Specifications
About this item
CD22 mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. [UniProt].
Functional Activity (Order SAF formulation) Flow Cytometry: 0,5-1 µg/million cells in 0,1 ml Immunofluorescence: 0,5 - 1 µg/ml Optimal dilution of the CD22 antibody should be determined by the researcher.
Type: Primary
Antigen: CD22
Clonality: Monoclonal
Clone: FR10B4
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human