- Conf:0,05 mg
- Tipo di enzima:Recombinant
- Sorgente luminosa:E. coli
- Specie:Human
- Sequenza tag:N-6 His tag
- Condizioni di conservazione:Store at −20 °C, stable for 6 months after receipt, please minimise freeze - thaw cycles
- Contenuto di endotossine:<0,1 ng/µg (1 IEU/µg) as determined by LAL test
- Nome dell'enzima:Aldehyde dehydrogenase 1-A2
- Sinonimi degli enzimi:Aldehyde dehydrogenase family 1 member A2, Retinaldehyde-specific dehydrogenase type 2, RALDH(II), Retinal dehydrogenase 2, ALDH1A2, RALDH2
- Purezza:>95% as determined by reducing SDS-PAGE
- Peso molecolare:58,2 kD
- Sequenza:Met1-Ser518
- Formulazione:Supplied as a 0,2 µm filtered solution of 20 mM TrisHCl, 150 mM NaCl, pH 7,5, 20% Glycerol. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilised protein in ddH₂O. Please aliquot the reconstituted solution to minimise freeze-thaw cycles.
Aldehyde dehydrogenase 1 family member A2 (ALDH1A2), also known as retinaldehyde dehydrogenase 2 (RALDH2), belongs to the aldehyde dehydrogenase family which contains two members, the ALDH1 s (ALDH1A1, ALDH1A2 and ALDH1A3) and the 9-cis retinaldehyde dehydrogenase ALDH8 s.
This recombinant protein can be used for biological assays. For research use only.
Fusion-Tag: N-6 His tag
ALDH1A2 is key enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. RA is a paracrine hormone signaling molecule that functions in developing and adult tissues. ALDH1A2 was also found to regulate normal and tumor cell growth and differentiation. Several studies showed that ALDH1A2 expression is increased after the appearance of AraC resistance in clinical cases which means this protein is effective in AraC resistance.