Anti-DNA Ligase IV/LIG4 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
BOSSBS-1677R-A750
: Bioss
- Tipo anticorpo:Primary
- Tipo di anticorpi:DNA Ligase IV/LIG4
- Clonalità:Policlonale
- Coniugazione:Alexa Fluor® 750
- Ospite:Rabbit
- ImmunoChimica:Yes
- ImmunoFluorescenza:Yes
- Isotipo:IgG
- Reattività:Human
- Western blot:Yes
- Epitopo:51-150/911
- Forma:Liquid
- ID gene:3981
- Sinomini antigene:DNA ligase IV|Polydeoxyribonucleotide synthase [ATP] 4|LIG4S|DNA ligase 4|LIG4
- Modifica:Unmodified
- Tampone di conservazione:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Peso molecolare:104 kDa
- Temperatura di conservazione:Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentrazione:1 µg/µl
- Temperatura di spedizione:4 °C
- Immunogeno:KLH conjugated synthetic peptide derived from human DNA Ligase IV
- Applicazioni testate:ICC
- Purificazione:Purified by Protein A
- Tipo di conf.:Vial
- Conf:100 µl
Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
Type: Primary
Antigen: DNA Ligase IV/LIG4
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 51-150/911
Host: Rabbit
Isotype: IgG
Reactivity: Human