Specifications
- Tipo anticorpo:Primary
- Tipo di anticorpi:Dynamin 1
- Clonalità:Policlonale
- Coniugazione:Alexa Fluor® 750
- Ospite:Rabbit
- ImmunoChimica:Yes
- ImmunoFluorescenza:Yes
- Isotipo:IgG
- Western blot:Yes
- Epitopo:551-680/864
- Forma:Liquid
- ID gene:1759
- Sinomini antigene:DYN1_HUMAN|DNM1|Dynamin-1|B dynamin|DNM|DNM 1|Dynamin|Dynamin1|D100
- Modifica:Unmodified
- Tampone di conservazione:Aqueous buffered solution containing 0,01M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol.
- Peso molecolare:97 kDa
- Temperatura di conservazione:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentrazione:1 µg/µl
- Temperatura di spedizione:4 °C
- Immunogeno:KLH conjugated synthetic peptide derived from human Dynamin 1
- Applicazioni testate:ICC
- Purificazione:Purified by Protein A
- Tipo di conf.:Vial
- Conf:100 µl
Specifications
About this item
Dynamin I is a GTPase enzyme required for the retrieval of synaptic vesicles after exocytosis and functions in endocytosis by stimulating assembly of invaginating synaptic vesicles (1). Dynamin I is phosphorylated in nerve terminals exclusively in the cytosolic compartment and in vitro by protein kinase C (PKC) (25). The phosphorylation site in PKC-phosphorylated Dynamin I is a single site at Serine 795, which is located near a binding site for the SH3 domain of p85, the regulatory subunit of phosphatidylinositol 3-kinase (25). Dephosphorylation is required for synaptic vesicle retrieval, suggesting that phosphorylation affects the subcellular localization of Dynamin I (5). Mouse, rat and human Dynamin I are phosphorylated on serine residues, including Ser 778, by Cdk5, regulating PACSIN1 recruitment and enabling synaptic vesicle endocytosis.
Type: Primary
Antigen: Dynamin 1
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 551-680/864
Host: Rabbit
Isotype: IgG
Reactivity: