Interleukin 10 (IL-10) is an anti-inflammatory cytokine produced by macrophages and type 2 T helper (Th2) cells. IL-10 inhibits the production of pro-inflammatory cytokines such as interferon gamma (IFN-ƴ), tumor necrosis factor alpha (TNF-α), interleukin 2 (IL-2), interleukin 3 (IL-3), interleukin 4 (IL-4), and granulocyte-macrophage colony-stimulating factor (GM-CSF), made by macrophages and regulatory T cells. IL-10 also suppresses antigen presentation on antigen presenting cells, and enhances the survival, proliferation, and antibody production of B cells.
- High quality
- Low endotoxin
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It inhibits the production of pro-inflammatory cytokines such as interferon gamma (IFNƴ), tumor necrosis factor alpha (TNFα), interleukin 2 (IL-2), interleukin 3 (IL-3), interleukin 4 (IL-4), and granulocyte-macrophage colony-stimulating factor (GM-CSF), made by macrophages and regulatory T cells. Mouse IL-10 is not active on human cells.
- Coniugazione:Non coniugato
- Protein function:Cytokine
- Protein/peptide type:Recombinant
- Sorgente luminosa:E. coli
- Specie:Rat
- Condizioni di conservazione:−20 °C
- Contenuto di endotossine:Endotoxin LAL (EU/µg) ≤0.1
- Attività biologica:Bioactivity: No biological activity data is available at this time
- ID gene:P29456
- Ricostituzione:Sterile water at 0,1 mg/ml
- Privo di endotossine:N
- Senza corriere:Y
- Protease-free:N
- Senza animali:Y
- Protein synonyms:Cytokine synthesis inhibitory factor|CSIF
- UniProtKB:P29456
- Protein/peptide name:IL-10
- Purezza:≥95%
- Peso molecolare:18,8 kDa
- Sequenza:MSKGHSIRGD NNCTHFPVSQ THMLRELRAA FSQVKTFFQK KDQLDNILLT DSLLQDFKGY LGCQALSEMI KFYLVEVMPQ AENHGPEIKE HLNSLGEKLK TLWIQLRRCH RFLPCENKSK AVEQVKNDFN KLQDKGVYKA MNEFDIFINC IEAYVTLKMK N
- Livello di endotossine:Low
- Formulazione:0,1% Trifluoroacetic Acid (TFA)
- Esente da nucleasi:N
- Grado:RUO
- Temperatura di spedizione:RT
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