About this item
Interferon gamma (IFN-γ) is a type II interferon that is critical during adaptive and innate immune responses to infection. IFN-γ is produced by T cells and natural killer cells following antigen-specific activation. IFN-γ binds IFN-γ receptors (IFN-γ R1 and IFN-γ R2), which are expressed on most immune cells, to activate the JAK-STAT pathway. IFN-γ-induced signaling increases the expression of class 1 major histocompatibility complex (MHC) molecules. Human IFN-γ is not cross-reactive with mouse IFN-γ.
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- Low Endotoxin
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A COA is supplied with each product shipped detailing purity, formulation, biological activity, endotoxin levels, reconstitution instructions and recommended storage conditions. This product is for research use only and is not for use in humans.
Specifications
- Coniugazione:Non coniugato
- Protein function:Cytokine
- Protein/peptide type:Recombinant
- Sorgente luminosa:E. coli
- Specie:Human
- Condizioni di conservazione:–20 °C
- Contenuto di endotossine:Endotoxin LAL (EU/µg) ≤0,1
- Attività biologica:Bioactivity assay: Viral challenge assay using EMC virus on A549 cells, ED50 ≤0,75 ng/ml, Bioactivity ≥1,3×10⁶ units/mg
- ID gene:P01579
- Ricostituzione:Sterile water at 0.1 mg/ml
- Privo di endotossine:N
- Senza corriere:Y
- Protease-free:N
- Senza animali:N
- Protein synonyms:Type II interferon|T cell interferon|MAF|Immune Interferon
- Protein/peptide name:IFNg
- Purezza:≥95%
- Peso molecolare:16,9 kDa
- Sequenza:MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFQGR RASQ
- Livello di endotossine:Low
- Formulazione:10 mM sodium phosphate, 50 mM sodium chloride, pH 7,5
- Esente da nucleasi:N
- Grado:RUO
- Temperatura di spedizione:RT
- Applicazioni testate:Bioassay