Human Recombinant IL-17AF (from E. coli)

Nome del fornitore: Shenandoah Biotechnology

Certificati

Nome del fornitore: Shenandoah Biotechnology

Informazioni su questo articolo

Interleukin 17AF (IL-17AF) is a heterodimer that is composed of the interleukin 17A (IL-17A) and interleukin 17F (IL-17F) members of the IL-17 family of cytokines. IL-17AF is produced by T helper 17 cells (Th17) following interleukin 23 (IL-23) stimulation. IL-17AF signals through the IL-17RA/IL-17RC receptor complex and functions to regulate inflammatory responses. IL-17AF induces chemokine and airway neutrophilia production, similar in function to IL-17A and IL-17F homodimers. In regard to these functions, IL-17AF is less active than the IL-17A homodimer and shows greater activity than the IL-17F homodimer. Human and rat IL-17AF are active on mouse cells.

High quality
Low endotoxin
Affordable

Caution: For research use only.

Specifiche

Coniugazione:
Non coniugato
Protein function:
Cytokine
Protein/peptide type:
Recombinant
Sorgente luminosa:
E. coli
Specie:
Human
Condizioni di conservazione:
–20 °C
Contenuto di endotossine:
Endotoxin LAL (EU/µg) ≤1
Attività biologica:
Bioactivity Assay: Production of IL-6 from mouse 3T3 cells, ED₅₀ ≤50 ng/ml, Bioactivity ≥2,0×10⁴ units/mg
ID gene:
Q16552/Q96PD4
Ricostituzione:
Sterile water at 0,1 mg/ml
Privo di endotossine:
N
Senza corriere:
Y
Protease-free:
N
Senza animali:
N
Protein/peptide name:
IL-17AF
Purezza:
≥95%
Peso molecolare:
30,7 kDa
Sequenza:
IL-17A:MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA IL-17F:MRKIPKVGHT FFQKPESCPP VPGGSMKLDI GIINENQRVS MSRNIESRST SPWNYTVTWD PNRYPSEVVQ AQCRNLGCIN AQGKEDISMN SVPIQQETLV VRRKHQGCSV SFQLEKVLVT VGCTCVTPVI HHVQ
Livello di endotossine:
Low
Formulazione:
0,1% Trifluoroacetic acid (TFA)
Esente da nucleasi:
N
Grado:
RUO
Temperatura di spedizione:
RT
Applicazioni testate:
Bioassay