Human Recombinant IL-1B (from E. coli)
Supplier: Shenandoah Biotechnology
Certificates
About this item
Interleukin 1 beta (IL-1β) is a pro-inflammatory cytokine that is produced by monocytes, macrophages, and dendritic cells (DCs). IL-1β signals through the IL-1 receptor, type 1 (IL-1R1) to activate the myeloid differentiation primary response 88 (MYD88) signaling pathway, which contains the cytoplasmic Toll/IL-1 receptor (TIR) domain adapter.
- High quality
- Low endotoxin
- Affordable
IL-1β and the independently regulated IL-1α protein have overlapping pro-inflammatory activities to induce adhesion molecule expression on epithelial cells, control fever induction, initiate rheumatoid arthritis, and promote septic shock.
Delivery: A certificate of analysis (COA) is supplied with each product shipped detailing purity, formulation, biological activity, endotoxin levels, reconstitution instructions and recommended storage conditions.
Caution: For research use only.
Specifications
- Coniugazione:Non coniugato
- Protein function:Cytokine
- Protein/peptide type:Recombinant
- Sorgente luminosa:E. coli
- Specie:Human
- Condizioni di conservazione:−20 °C
- Contenuto di endotossine:Endotoxin LAL (EU/µg) ≤1
- Attività biologica:Bioactivity assay: D10S cell proliferation, ED50 ≤0,012 ng/ml, bioactivity ≥8,3×10⁷ units/mg
- ID gene:P01584
- Ricostituzione:Sterile water at 0,1 mg/ml
- Privo di endotossine:N
- Senza corriere:Y
- Protease-free:N
- Senza animali:N
- Protein synonyms:EP|Catabolin|LAF|LEM|MCF
- UniProtKB:P01584
- Protein/peptide name:IL-1 beta
- Purezza:≥95%
- Peso molecolare:17,5 kDa
- Sequenza:MAPVRSLNCT LRDSQQKSLV MSGPYELKAL HLQGQDMEQQ VVFSMSFVQG EESNDKIPVA LGLKEKNLYL SCVLKDDKPT LQLESVDPKN YPKKKMEKRF VFNKIEINNK LEFESAQFPN WYISTSQAEN MPVFLGGTKG GQDITDFTMQ FVSS
- Livello di endotossine:Low
- Formulazione:10 mM sodium phosphate, pH 7,5
- Esente da nucleasi:N
- Grado:RUO
- Temperatura di spedizione:RT
- Applicazioni testate:Bioassay
Specifications
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