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Mouse recombinant TNC:TWEAK (soluble)
Mouse recombinant TNC:TWEAK (soluble)
Codice catalogo ENZOALX522138C010
Nome del fornitore:  ENZO LIFE SCIENCES
Numero CAS:  
Mouse recombinant TNC:TWEAK (soluble)
Codice catalogo ENZOALX522138C010
Nome del fornitore:  ENZO LIFE SCIENCES
Numero CAS:  

Specifiche

  • Conf:
    10 µG
  • Protein/peptide type:
    Recombinant
  • Specie:
    Mouse
  • Seq:
    02
  • Ricostituzione:
    Reconstitute with 100 µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
  • Protein/peptide name:
    TNC:TWEAK (soluble)
  • Purezza:
    >95% (SDS-PAGE)
  • Concentrazione:
    0,1 mg/ml after reconstitution
  • Formulazione:
    Lyophilised. Contains PBS.

Specifiche

Informazioni su questo articolo

Produced in HEK 293 cells. The extracellular domain of mouse TWEAK (aa 94-249) is fused at the N-terminus to tenascin-C (TNC) (chicken) (aa 110-139) and a FLAG®-tag.

Some TNF ligands (such as TWEAK (mouse) or FasL (mouse)) produced as soluble forms do not assemble into stable trimers and show low receptor binding.

Addition of the tenascin-C oligomerization domain (TNC) (from chicken) at the N-terminus of recombinant mouse soluble TWEAK stabilizes the TNF homology domain (THD) of rmsTWEAK into a trimer and increases binding to its respective TNF receptor.

Note: For some TNF ligands, such as FasL (mouse), activated by further oligomerization (> hexamer), the presence of TNC is not sufficient and ligand crosslinking using the 'Enhancer for Ligands' (Prod. No. ALX-804-034) is required.