Specifiche
- Conf:10 µG
- Protein/peptide type:Recombinant
- Sorgente luminosa:CHO cells
- Specie:Human
- Seq:02
- Attività biologica:Binds to human CD40. Induces B cells activation (as demonstrated by dose-dependent upregulation of CD86).
- Ricostituzione:Reconstitute with 100 µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
- Protein/peptide name:MegaCD40L™ (soluble)
- Purezza:>90% (SDS-PAGE)
- Concentrazione:0,1 mg/ml after reconstitution
- Formulazione:Lyophilised. Contains PBS.
Specifiche
Informazioni su questo articolo
High-activity, high-purity CD40L construct for immune activation
Produced in CHO cells. The extracellular domain of human CD40L (CD154) (aa 116-261) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG®-tag.
MegaCD40L™ is a high-activity construct in which two trimeric CD40 ligand molecules are artificially linked via the collagen domain of Adiponectin/ACRP30/AdipoQ. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to [CD40L+enhancer] combinations (Prod. No. ALX-850-064).
* Purity - 10- to 100-fold lower Endotoxin levels than comparable products
* Activity – MegaCD40L™ oligomer mimics in vivo membrane-assisted CD40L aggregation and stimulation without the need for enhancers
* Consistency – Experienced manufacturing results in dependable lot-to-lot performance
* Stability – Optimized formulation for improved stability and enhanced activity