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Human Recombinant Glycine N-Methyltransferase (from E. coli)
Human Recombinant Glycine N-Methyltransferase (from E. coli)
Codice catalogo PRSI91-999
Nome del fornitore:  ProSci Inc.
Numero CAS:  
Human Recombinant Glycine N-Methyltransferase (from E. coli)
Codice catalogo PRSI91-999
Nome del fornitore:  ProSci Inc.
Numero CAS:  

Specifiche

  • Conf:
    50 µG
  • Tipo di enzima:
    Recombinant
  • Sorgente luminosa:
    E. coli
  • Specie:
    Human
  • Sequenza tag:
    N-6 His tag
  • Condizioni di conservazione:
    Store at −20 °C, stable for 6 months after receipt. Please minimize freeze−thaw cycles.
  • Nome dell'enzima:
    Glycine N-Methyltransferase
  • Purezza:
    >95% as determined by reducing SDS-PAGE
  • Peso molecolare:
    34.9 kD
  • Sequenza:
    Met1-Asg294
  • Formulazione:
    Supplied as a 0.2 µm filtered solution of 20 mM TrisHCl, 150 mM NaCl, pH 8.0. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
  • Applicazioni testate:
    Bioassay

Specifiche

Informazioni su questo articolo

Glycine N-Methyltransferase (GNMT) is a tetrameric cytosolic protein. GNMT catalyses the synthesis of N-methylglycine from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. It can affects DNA methylation by regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine, playing an important role in maintaining normal AdoMet levels. GNMT is highly expressed in liver. As a major folate-binding protein, GNMT takes part in the detoxification pathway. Defects in GNMT are the cause of hypermethioninemia. the patients with this deficiency are mild hepatomegaly and chronic elevation of serum transaminases.

Fusion-Tag: N-6 His tag

This recombinant protein can be used for biological assays. For research use only.