Specifiche
- Conf:50 µG
- Tipo di enzima:Recombinant
- Sorgente luminosa:Cells
- Specie:Human
- Sequenza tag:C-6 His tag
- Condizioni di conservazione:Store at −20 °C, stable for 6 months after receipt. Please minimize freeze−thaw cycles.
- Nome dell'enzima:N-Acetylglucosamine-6-Sulfatase
- Purezza:>95% as determined by reducing SDS-PAGE
- Peso molecolare:59.35 kD
- Sequenza:Val37-Leu552
- Formulazione:Supplied as a 0.2 µm filtered solution of 20 mM TrisHCl, 150 mM NaCl, pH 8.0. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- Applicazioni testate:Bioassay
Specifiche
Informazioni su questo articolo
N-Acetylglucosamine-6-Sulfatase is a member of the Sulfatase family. N-Acetylglucosamine-6-Sulfatase is required for the lysosomal degradation of the Glycosaminoglycans (GAG) Heparan Sulfate and Keratan Sulfate. N-Acetylglucosamine-6-Sulfatase hydrolyses the 6-Sulfate groups of the N-Acetyl-D-Glucosamine 6-Sulfate units of Heparan Sulfate and Keratan Sulfate. N-Acetylglucosamine-6-Sulfatase binds 1 Calcium ion per subunit. N-Acetylglucosamine-6-Sulfatase deficiency are the cause of Mucopolysaccharidosis Type 3D (MPS3D), an inborn error leading to lysosomal accumulation of heparan sulfate. MPS3D has profound mental deterioration, hyperactivity, and relatively mild somatic manifestations.
Fusion-Tag: C-6 His tag
This recombinant protein can be used for biological assays. For research use only.