Specifiche
- Tipo anticorpo:Primary
- Tipo di anticorpi:Nucleophosmin
- Simbolo dell'antigene:NPM
- Clonalità:Policlonale
- Coniugazione:Cy7®
- Ospite:Rabbit
- ImmunoChimica:Yes
- Isotipo:IgG
- Reattività:Human,Rat,Mouse
- Assorbimento incrociato:No
- Forma:liquid
- ID gene:4869
- Sinomini antigene:MGC104254|NO38|Nucleophosmin|Nucleolar protein NO38|numatrin|B23|Nucleolar phosphoprotein B23|NPM1
- Tampone di conservazione:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Temperatura di conservazione:Store at 4°C for 12 months
- Concentrazione:1 μg/μl
- Temperatura di spedizione:4°C
- Immunogeno:1-50/259
- Purificazione:Purified by Protein A
- Conf:100 µl
Specifiche
Informazioni su questo articolo
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: NPM
Clonality: Polyclonal
Clone:
Conjugation: Cy7®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat