This antibody recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
Type: Primary
Antigen: TYMS
Clonality: Monoclonal
Clone: TS106
Conjugation: CF647
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human
- Catalog No:
- BNC470714-100
- BNC470714-500
- Simbolo dell'antigene:
- TYMS
- TYMS
- Tipo di anticorpi:
- Thymidylate Synthase
- Thymidylate Synthase
- Sinomini antigene:
- TSase|TS|TMS|Tyms thymidylate synthetase|dTMP synthase|TYMS protein
- TSase|TS|TMS|Tyms thymidylate synthetase|dTMP synthase|TYMS protein
- Tipo anticorpo:
- Primary
- Primary
- Clonalità:
- Monoclonale
- Monoclonale
- Coniugazione:
- CF® 647
- CF® 647
- Clone:
- Clone TS106
- Clone TS106
- Reattività:
- Human
- Human
- Ospite:
- Mouse
- Mouse
- ID gene:
- 369762
- 369762
- Isotipo:
- IgG1 kappa
- IgG1 kappa
- ImmunoChimica:
- Yes
- Yes
- ImmunoFluorescenza:
- Yes
- Yes
- Concentrazione:
- 0,1 mg/ml
- 0,1 mg/ml
- Tampone di conservazione:
- PBS/0,1% BSA/0,05% azide
- PBS/0,1% BSA/0,05% azide
: VWR Chemicals
: KIMBERLY CLARK
: VWR Collection
: VWR Chemicals
: VWR Collection
: VWR Collection
: VWR Collection
: VWR Collection