Specifiche
- Tipo anticorpo:Primary
- Tipo di anticorpi:G Protein-Coupled Receptor Kinase Interacting ArfGAP 1
- Simbolo dell'antigene:GIT1
- Clonalità:Policlonale
- Coniugazione:Non coniugato
- Ospite:Rabbit
- ImmunoChimica:Yes
- Isotipo:IgG
- Reattività:Human
- Western blot:Yes
- Forma:liquid
- ID gene:28964
- Sinomini antigene:ARF GTPase-activating protein GIT1|GIT16|Cat-1|G protein-coupled receptor kinase-interactor 1|GRK-interacting protein 1|Cool-associated and tyrosine-phosphorylated protein 1
- Modifica:Ser375
- Tampone di conservazione:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0,09% sodium azide. Store at -20°C for 12 months.
- Concentrazione:1 ug/ul
- Temperatura di spedizione:4 °C
- Purificazione:Purified by Protein A.
- Taglia:100 μg
- Conf:100 µl
Specifiche
Informazioni su questo articolo
Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist (1,2). G protein-coupled receptor kinases (GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade (3,4). GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking (5,6). GIT1 overexpression results in reduced internalization and resensitization of b2-adrenergic receptor, thus reducing b2-adrenergic receptor signaling (5).
WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Type: Primary
Antigen: GIT1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human