- Tipo anticorpo:Primary
- Tipo di anticorpi:dedicator of cytokinesis 4
- Simbolo dell'antigene:DOCK4
- Clonalità:Policlonale
- Coniugazione:Non coniugato
- Ospite:Rabbit
- ImmunoChimica:Yes
- Isotipo:IgG
- Reattività:Human,Rat,Mouse
- Western blot:Yes
- Forma:liquid
- ID gene:9732
- Sinomini antigene:Dock4|KIAA0716.|Dedicator of cytokinesis protein 4|DOCK4_HUMAN
- Tampone di conservazione:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0,09% sodium azide. Store at -20°C for 12 months.
- Concentrazione:1 ug/ul
- Temperatura di spedizione:4 °C
- Purificazione:Purified by Protein A.
- Taglia:100 μg
- Conf:100 µl
DOCK 4 is a cytoplasmic peripheral membrane protein that belongs to the DOCK family of cytokinesis-regulating proteins. Expressed ubiquitously with highest expression in prostate, ovary and skeletal muscle, DOCK 4 functions as a guanine nucleotide exchange factor (GEF) that activates the small GTPase Rap 1 and, via this activation, plays a role in the regulation of adherens junctions between cells. Similar to other DOCK family members, DOCK 4 contains an N-terminal SH3 domain, a C-terminal proline-rich region and two internal DOCK homology regions designated DHR1 and DHR2. Defects in the gene encoding DOCK 4 result in the inactivation of Rap 1 and are, thus, implicated in the pathogenesis of various cancers such as ovarian, prostate, glioma and colorectal carcinomas. Four isoforms of DOCK 4 are expressed due to alternative splicing events.
WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Type: Primary
Antigen: DOCK4
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat