Specifiche
- Tipo anticorpo:Primary
- Simbolo dell'antigene:DOCK3
- Clonalità:Policlonale
- Coniugazione:Non coniugato
- Ospite:Rabbit
- ImmunoChimica:Yes
- Isotipo:IgG
- Reattività:Human,Rat,Mouse
- Western blot:Yes
- Forma:liquid
- Sinomini antigene:DOCK 3|MOCA|Presenilin binding protein|Dedicator of cytokinesis protein 3|DOCK3_HUMAN.|Modier of cell adhesion
- Tampone di conservazione:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0,09% sodium azide. Store at -20°C for 12 months.
- Concentrazione:1 ug/ul
- Temperatura di spedizione:4 °C
- Purificazione:Purified by Protein A.
- Taglia:100 μg
- Conf:100 µl
Specifiche
Informazioni su questo articolo
MOCA (modifier of cell adhesion), also known as Presenilin-binding protein (PBP) or dedicator of cytokinesis protein 3 (DOCK3), is a 2030 amino acid cytoplasmic protein belonging to the DOCK family. MOCA interacts with Presenilin proteins and has the ability to stimulate Tau phosphorylation suggesting that MOCA may be involved in Alzheimer disease. MOCA is also thought to be a guanine nucleotide exchange factor (GEF) which activates small GTPases by exchanging bound GDP for free GTP. Analysis of ectopic expression suggests that MOCA may affect the function of small GTPases involved in the regulation of Actin cytoskeleton or cell adhesion receptors. MOCA is localized to the neuropil, and sometimes in pyramidal cells, in normal brains, while in Alzheimer disease brains, MOCA is present in neurofibrillary tangles.
WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Type: Primary
Antigen: DOCK3
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat