STAT2 (Signal transducer and activator of transcription 2), 113kDa, is a member of the STAT family of cytoplasmic transcription factors. STAT members generally mediate cytokine, growth factor and hormone receptor signal transduction. STAT2 is a transcription factor critical to the signal transduction pathway of type I interferons (e.g. IFNα). STAT2 resides primarily in the cytoplasm and is tyrosine-phosphorylated after IFNα binds to cell surface receptors. In response to tyrosine phosphorylation STAT2 rapidly localizes to the nucleus and acquires the ability to bind specific DNA targets in association with two other proteins, STAT1 and IFN regulatory factor-9 (IRF-9). STAT2 is phosphorylated at Y689 by receptor-associated Janus kinasses (JAKs) leading to STAT2 dimerization and subsequent translocation to the nucleus to activate gene transcription.

Western Blot: 1:2,000;

Type: Primary
Antigen: STAT2 (signal transducer and activator of transcription 2, 113kDa)
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human