Receptor-type tyrosine-protein phosphatase eta(Also known as DEP1; SCC1; CD148; HPTPeta; R-PTP-ETA) is an enzyme that in humans is encoded by the PTPRJ gene.[1][2][3]
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This PTP is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 (PLCG1) and Linker for Activation of T Cells (LAT). This PTP was also found to dephosphorylate PDGF beta receptor, and may be involved in UV-induced signal transduction.[3]
PTPRJ has been shown to interact with CTNND1.[4]

Western Blot: 1:2000;

Type: Primary
Antigen: PTPRJ (protein tyrosine phosphatase, receptor type, J)
Clonality: Monoclonal
Clone: T23-5E6
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2b
Reactivity: Human