Casein kinases are a group of ubiquitous Ser/Thr kinases that phosphorylate key regulatory proteins involved in the control of cell differentiation, proliferation, chromosome segregation, circadian rhythms, and metabolic pathways. CK1 family members share a highly conserved kinase domain but differ in their variable N- and C-terminal domains. Mammals have seven family members: α, β, γ1, γ2, γ3, δ, and ε. They all share at least 50% amino acid identity within the protein kinase catalytic domain. CK1 isoforms exclusively use ATP as phosphate donor and are generally co-factor independent.
Casein kinase 1 δ is ubiquitously expressed in all tissues, is p53 dependently induced in stress situations and plays an important role in various cellular processes. PKA phosphorylates CK1δ, predominantly at Ser370 in vitro and in vivo, and that site-specific phosphorylation of CK1δ by PKA plays an important role in modulating CK1δ-dependent processes.

Western Blot: 1:5,000; Immunoprecipitation: 2 ?l;

Type: Primary
Antigen: CSNK1D (casein kinase 1, delta)
Clonality: Monoclonal
Clone: AF12G4
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2b Kappa
Reactivity: Human, Mouse, Rat