Dual specificity phosphatase(DUSP) inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. DUSPs can be divided into six subgroups on the basis of sequence similarity(PRLs, Cdc14 phosphatases, PTENs, myotubularins, MKPs, atypical DUSPs). DUSP inhibitors might be used to manipulate MAPK and cellular responses in both positive and negative ways. The regulated expression and activity of DUSP family members in different cells and tissues controls MAPK intensity and duration to determine the type of physiological response.
DUSP12(YVH1, GKAP) contains the consensus DUSP catalytic domain as well as an extended C-terminal domain of unknown function, thought to be related to its potential role in glucokinase regulation. It is localized in the cytoplasm and nucleus.

ELISA Western Blot(1:5,000;

Type: Primary
Antigen: DUSP12 (dual specificity phosphatase 12)
Clonality: Monoclonal
Clone: AF28B2
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1 Kappa
Reactivity: Human