There are ten mitogen-activated protein kinase (MAPK) phosphatases
(MKPs) that act as negative regulators of MAPK activity in mammalian
cells.
MKP4(DUSP9) is a dual specificity phosphatase, which acts as a negative
regulator of insulin-stimulated pathways. MKP4 is expressed in kidney,
placenta and adipose tissue. MKP4, a cytosolic MKP with specificity to not
only Erk, but also, to a lesser extent, JNK and p38. MKP4 also reversed
the effect of TNF-a to inhibit insulin Signaling. MKP4 has a protective
effect against the development of insulin resistance through its ability to
dephosphorylate and inactivate crucial mediators of stress-induced insulin
resistance.

Western Blot: 1:2,000;

Type: Primary
Antigen: DUSP9 (dual specificity phosphatase 9)
Clonality: Monoclonal
Clone: AF11B5
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1 Kappa
Reactivity: Human