Specifications
- Tipo anticorpo:Primary
- Tipo di anticorpi:integrin-linked kinase
- Simbolo dell'antigene:ILK
- Clonalità:Monoclonale
- Clone:AF22F1
- Coniugazione:Non coniugato
- ELISA:Yes
- Ospite:Mouse
- Isotipo:IgG1
- Reattività:Human,Rat,Mouse
- Western blot:Yes
- Assorbimento incrociato:none
- ID gene:3611
- Sinomini antigene:HEL-S-28|p59ILK|ILK-1|ILK-2|P59
- Temperatura di conservazione:Store for 1 year at –20 °C from date of shipment
- Concentrazione:1 mg/ml
- Temperatura di spedizione:Ice
- Immunogeno:Recombinant human protein purified from E.coli (His-ILK)
- Purificazione:Protein G purified
- Taglia:100 µl
- Conf:0,1 mL
Specifications
About this item
Integrin-linked kinase (ILK) is an adaptor and signaling protein that couples integrins to the actin cytoskeleton and coordinates signal transduction from extracellular matrix and growth factors.
By interacting with the focal adhesion proteins PINCH, paxillin, and parvin, ILK regulates integrin- mediated cell adhesion and cytoskeletal dynamics within focal adhesions to regulate cell adhesion, spreading, and migration.
ILK is involved in the suppression of apoptosis and promotion of cell survival through the phosphorylation of AKT(Ser473), GSK-3(Ser9), myosin light chain(Ser18/19), and affixin.
ILK activity is stimulated by PI3 kinase and negatively regulated by the tumor suppressor PTEN.
Western Blot: 1.0 ?g/ml;
Type: Primary
Antigen: ILK (integrin-linked kinase)
Clonality: Monoclonal
Clone: AF22F1
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1 Kappa
Reactivity: Human, Mouse, Rat