There are ten mitogen-activated protein kinase (MAPK) phosphatases (MKPs) that act as negative regulators of MAPK activity in mammalian cells.
MKP2(DUSP4) is a dual threonine/tyrosine phosphatase that specifically dephosphorylates and inactivates MAPKs(ERK, JNK, p38). It contains one Rhodanese domain and one tyrosine-protein phosphatase domain.
MKP2 is expressed in a variety of tissues, and is localized in the nucleus.
Transcription factor E2F-1 acts as a transcriptional regulator of MKP2. E2F-1/MKP2 pathway mediates apoptosis under oxidative stress and that MKP2 suppresses tumor formation.
MKP2 is a novel transcription target of p53 in mediating apoptosis by 10-bp palindrome motif (CTGGCGCCAG) in the MKP2 promoter.

Western Blot: 1:2,000;

Type: Primary
Antigen: DUSP4 (dual specificity phosphatase 4)
Clonality: Monoclonal
Clone: AFPK7
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1 Kappa
Reactivity: Human