p21, also known as cyclin-dependent kinase inhibitor 1A or CDKN1A, directly inhibits the activity of cyclin-cdk2 and cyclin-cdk4 complexes. It mainly inhibits the activity of cyclin/cdk2 complexes and negatively modulates cell cycle progression. p21 also plays other fundamental roles including transcriptional regulation and the modulation of apoptosis.
p21 forms part of a family of structurally related proteins comprising p21, p27 and p57 that all share the ability to inhibit a wide range of cyclin -dependent kinase holoenzymes.
Besides its cdk inhibitor function, p21 is recognized to play a wide variety of physiological roles, many of which rely on its nuclear localization. p21 can bind to proliferating cell nuclear antigen (PCNA) thereby blocking DNA synthesis. p21 functions as a regulator of cell cycle progression at S phase. The expression of p21 is controlled by the tumor suppressor protein p53. Each of these functions of p21 is achieved through direct p21/protein interactions and the subcellular localization of p21 plays an important part in dictating the binding partners to which p21 is exposed.

Western Blot: 0.5 ?g/ml;

Type: Primary
Antigen: H3F3AP6 (H3 histone, family 3A, pseudogene 6)
Clonality: Monoclonal
Clone: AF9D10
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1 Kappa
Reactivity: Human