Serum amyloid P component (SAP) is a normal plasma protein and a universal non-fibrillar constituent of amyloid deposits. SAP is a member of the pentraxin protein family which includes C-reactive protein. Human SAP is secreted and catabolized only by hepatocytes, and consists of five identical non-covalently associated subunits, each with a molecular mass of 25 kDa, which are non-covalently associated in a pentameric disc-like ring. SAP is a calcium-dependent ligand binding protein, which binds to DNA and chromatin, and to all known types of amyloid fibrils accounting for its specific accumulation in amyloid deposits. Serum amyloid P component scintigraphy is a non-invasive and quantitative method for imaging amyloid deposits, which produces diagnostic images in most patients with systemic amyloidosis, and can be used repeatedly to monitor the course of the disease.

Western Blot: 1:1,000; Immunoprecipitation: 1 ?l;

Type: Primary
Antigen: APCS (amyloid P component, serum)
Clonality: Monoclonal
Clone: 6000000
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1 Kappa
Reactivity: Human