Anti-Ubiquitin +1 Mouse Monoclonal Antibody [clone: 40B3]

ABFRLF-MA0087

ABFRLF-MA0087

Tipo anticorpo:
Primary
Tipo di anticorpi:
Ubiquitin A-52 Residue Ribosomal Protein Fusion product 1
Simbolo dell'antigene:
UBA52
Clonalità:
Monoclonale
Clone:
40B3
Coniugazione:
Non coniugato
Ospite:
Mouse
ImmunoPrecipitazione:
Yes
Isotipo:
IgG1
Reattività:
Human
Western blot:
Yes
Assorbimento incrociato:
none
ID gene:
7311
Sinomini antigene:
RPL40|CEP52|L40|HUBCEP52
Temperatura di conservazione:
Store for 1 year at –20 °C from date of shipment
Temperatura di spedizione:
Ice
Immunogeno:
Synthetic peptide (KLH coupled) corresponding to C-terminal residues of human Ubiquitin +1.
Purificazione:
Ammonium sulfate precipitation
Taglia:
100 µl
Conf:
0,1 mL

Ubiquitin+1 (Ub+1) is a novel mutant form of ubiquitin that can be produced through a process known as molecular frameshift. Ub+1 can be polyubiquitinated to produce aberrant polyubiquitin chains that inhibit the 26S proteasome. Especially ub+1 is accumulated in aggregates containing amyloid-β and phosphorylated-tau. Elevated expression of Ub+1 mRNA and protein has been observed in the brains of patients with Alzheimer's disease. Also ub +1 acts as an aggravating factor in polyglutamine-induced neuro-degeneration.

Western Blot: 1:500-1000; Immunoprecipitation: 1-2 ?l;

Type: Primary
Antigen: Ubiquitin +1 (ubiquitin +1)
Clonality: Monoclonal
Clone: 40B3
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1 Kappa
Reactivity: Human