Hai cercato: Proteine e Peptidi

Supplier: ENZO LIFE SCIENCES

Guanylyl cyclase activator

Supplier: ENZO LIFE SCIENCES

Produced in E. coli. Dimer of two identical subunits (119 aa) linked together by very strong hydrophobic interactions.

Supplier: ENZO LIFE SCIENCES

Produced in E. coli. Homologous to human serum leptin.

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Caspase-9 substrate

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Inhibitor of TNF-alpha processing

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Isolated from rabbit liver. Mixture of MT isoforms. Contains mainly MT-1a and MT-2e and a minor portion of MT-2d.

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Highly active

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Produced in HEK 293 cells. The extracellular domain of human LIGHT (aa 89-240) is fused at the N-terminus to a linker peptide (10 aa) and a FLAG®-tag.

Supplier: ENZO LIFE SCIENCES

This peptide sequence, RRRAAEELDSRAGpSPQL, corresponds to the sequence of the epsilon subunit of elF2B surrounding Ser540, a target of GSK-3 (glycogen synthase kinase 3) phosphorylation, with the addition of a phosphoserine in the 4 position.

Supplier: ENZO LIFE SCIENCES

Produced in Sf9 cells.

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Produced in yeast. Recombinant human granzyme B (aa 21-247).

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MMP-2 substrate

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Inhibitor of caspase-1 and -4

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Isolated from bovine eye lens.

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Produced in E. coli. Full length human CDC25C.

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Produced in E. coli.

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MG-132 is a potent, cell permeable and selective proteasome inhibitor (Ki = 4 nM).1 It inhibits NF-κB activation by preventing IκB degradation (IC50 = 3 μM). The peptide blocks degradation of short-lived proteins, which in turn induces HSP and ER chaperone expression, leading to thermotolerance (1 μM MG-132, 2 h.). It also stimulates neurite outgrowth in PC12 cells (20 nM optimal). The peptide has also been reported to increase the survival rate of mesenchymal stem cells following their transplantation. IC50’s for inhibition of Suc-LLVY-AMC and Z-LLL-AMC cleaving activities of proteasome were 0,85 and 0,1 μM respectively. The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems, thus blockade of UPS by MG-132 activates autophagy.

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Caspase inhibitor

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Human;Pig;Rat Endothelin 3

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Produced in insect cells.

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Produced in HEK 293 cells. The extracellular domain of human CD137L (aa 49-254) is fused at the N-terminus to a linker peptide (10 aa) and a FLAG®-tag.

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Analog of microcystin-LR (Prod. No. ALX-350-012) with Tyr substituted in place of Arg.

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Fluor de Lys® Substrate is a highly sensitive and convenient alternative to radiolabeled, acetylated histones or peptide/HPLC methods for the assay of histone deacetylases. The Fluor de Lys® Substrate, which comprises an acetylated lysine side chain, is incubated with a sample containing HDAC activity (nuclear or cellular extract, purified enzyme, bead-bound immunocomplex, etc.). Deacetylation of the substrate sensitizes the substrate so that, in a second step, treatment with the Fluor de Lys® Developer produces a fluorophore. Histone deacetylases from all known classes have been successfully assayed with the Fluor de Lys® Substrate. These include human HDACs 1, 2, 3 and 8 (class I), human HDACs 4 and 9 (class II) and the sirtuins yeast Sir2, human SIRT1 and human SIRT2 (class III; reaction must include the sirtuin substrate NAD+). The substrate is cell-permeable and serves as the basis for the HDAC Cellular Activity Assay Kit (Prod. No. BML-AK503). NOTE: Must be used in conjunction with Fluor de Lys® Developer (Prod. No. BML-KI105). Sufficient for 100-1000 assays of HDACs or sirtuins (50 µl reaction volume, 50-500 µM (substrate).

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AMPK and SIK kinase substrate

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Produced in E. coli. Human Ang-1 (angiopoietin-1) is a single, non-glycosylated polypeptide chain containing 480 amino acids (20 to 498)

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Produced in HEK 293 cells. The extracellular domain of human CD40L (CD154) (aa 116-261) is fused at the N-terminus to the Fc portion of human IgG1 and a linker peptide (20 aa).

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The HIGHDEF® DAB Chromogen/Substrate Set can be used in conjunction with peroxidase-based immunostaining systems. Peroxidase from the antibody detection system reacts with hydrogen peroxide substrate to degrade it, which then reacts with DAB, precipitating it at positive sites and yielding a dark brown color.

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Produced in E. coli. Active Matrix Metalloproteinase-10 (MMP-10, stromelysin-2, transin-2) catalytic domain from human cDNA.

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This BSA Solution (10%) is specially designed to create the Blocking Buffer and Assay Buffer in ImmunoSet products. Each bottle is sufficient for use with 5×96 wells microtiter plates if following the instructions in our ImmunoSet protocol. The BSA Solution may be used for any other assay development needs. Additional assay development reagents are available as companion products to our ImmunoSet products.

Supplier: Biosensis

Mouse NGF (2.5S) was isolated from mouse submaxillary glands by method of Mobley et al (1976) and is a form of beta-NGF that has identical biological properties. NGF is known to regulate the survival and development of certain sympathetic and sensory neurons. It is a dimer with 2 identical polypeptide chains and dimeric molecular weight of approximately 26,500 Da. Isolation and purification of NGF from mouse submaxillary glands yields preparations of NGF (2.5S) with identical biological activity but with cleavages at the amino terminus (with the loss of 8 amino acids) and/or at the carboxy-terminus (with the loss of arginine). These preparations are named 2.5 NGF.