233 Résultats pour : "Test Lead"
siRNA transfection reagent, Lullaby™
Supplier: OZ BIOSCIENCES
Lullaby™ is an ideal siRNA transfection reagent for gene silencing. Based on the TEE-technology, it has been successfully tested on numerous cell lines, reaching up to 90% gene silencing with high reproducibility and very low toxicity. RNA interference is a powerful technique to shut down genes expression in cells and organisms. This silencing effect constitutes a very helpful tool to study gene function and a promising approach for new therapeutic treatments.
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Anti-GRIN2B Rabbit Polyclonal Antibody
Supplier: ProSci Inc.
The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death. Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression. Tyr1472 on NR2B is phosphorylated and this may lead to the increased expression of the NMDAR at the synapse that plays a role in synaptic plasticity.
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Human recombinant STING AQ variant (from E. coli)
Supplier: Cayman Chemical
An active, pure human recombinant enzyme.
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Carbon LC columns, Supel™, Supelco®
Supplier: Merck
Porous Graphitic Carbon (PGC) particle packed column for separating poorly retained, polar compounds.
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Anti-EPHB2 Rabbit Polyclonal Antibody
Supplier: ProSci Inc.
EphrinB proteins are thought to play key roles in cellular functions as diverse as neuronal migration and blood vessel development (Flanagan and Vanderhaeghen, 1998; Dufour et al., 2003; Oike et al., 2002). EphrinB molecules expressed at the membrane surface bind to the EphB family receptors on target cells during cell-to cell contact. This interaction leads to cell signaling in the target cell but also generates a reverse signal in the cell expressing EphrinB on its surface. This reverse signaling event is thought to be critical for vessel maturation and neuronal development. Importantly, tyrosine phosphorylation of EphrinB is thought to be a critical component of this reverse signaling event (Palmer et al., 2002). Recent work suggests that phosphorylation of a specific EphrinB residue (Tyr298) plays a key role in EphrinB signaling (Kalo, et al., 2001).
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Supelco® BIOshell™ 400 Å Protein C18 Fused-Core® HPLC Columns
Supplier: Merck
BIOshell™ 400 Å Protein C18 columns contain 3,4 µm advanced Fused-Core® particles with 400 Å pores that are specifically engineered to provide efficient separation of large proteins.
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Microvascular Endothelial Cell Growth Medium, Basal
Supplier: PROVITRO
Microvascular Endothelial Cell Growth Medium, Advanced, is a sterile liquid culture medium designed for cultivating human microvascular endothelial cells (HMVEC). Delivered as a basal medium, it is suitable for culturing Provitro HMVEC upon the addition of supplement mix components.
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N'-(Éthylcarboneimidoyl)-N,N-diméthylpropane-1,3-diamine monochlorhydrate, grade Premium, Pierce™
Supplier: Thermo Fisher Scientific
Thermo Scientific Pierce Premium Grade EDC is our highest quality formulation of this popular carbodiimide crosslinker, specially characterized for applications where product integrity and risk minimization are paramount.
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Anti-EPHB2 Rabbit Polyclonal Antibody
Supplier: ProSci Inc.
EphrinB proteins are thought to play key roles in cellular functions as diverse as neuronal migration and blood vessel development (Flanagan and Vanderhaeghen, 1998; Dufour et al., 2003; Oike et al., 2002). EphrinB molecules expressed at the membrane surface bind to the EphB family receptors on target cells during cell-to cell contact. This interaction leads to cell signaling in the target cell but also generates a reverse signal in the cell expressing EphrinB on its surface. This reverse signaling event is thought to be critical for vessel maturation and neuronal development. Importantly, tyrosine phosphorylation of EphrinB is thought to be a critical component of this reverse signaling event (Palmer et al., 2002). Recent work demonstrated that Tyr331 of EphrinB was phosphorylated in HEK293 cells after stimulation by the soluble EphB2 receptor tyrosine kinase (Kalo et al., 2001).
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Anti-TrkA Mouse Monoclonal Antibody [clone: BS292]
Supplier: Biosensis
TrkA is a member of the neurotrophic tyrosine kinase receptor family. It is a membrane-bound receptor that upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). TrkA leads to cell differentiations and may play a role in specifying sensory neuron subtypes. It has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. SUBCELLULAR LOCATION: Cell membrane; single-pass type I membrane protein. Endocytosed to the endosomes upon treatment of cells with NGF. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. Both isoforms have similar biological properties. TISSUE SPECIFICITY: Isoform TrkA-II is primarily expressed in neuronal cells. Isoform TrkA-I is found in non-neuronal tissues. Mutations in TrkA have been associated with congenital insensitivity to pain, anhidrosis, self-mutalating behaviour, mental retardation and cancer (Reference: www.uniprot.com).
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Hepcidin (Rat) ELISA Kit
Supplier: Abcam
A sandwich ELISA kit for the qualitative detect Hepcidin in rat serum or plasma.
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MaxSpec® Dienes Derivatization Kit
Supplier: Cayman Chemical
Derivatization Kit for the sensitive LC-MS/MS analysis of dienes such as Vitamin D and Vitamin D metabolites.
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Human Erythropoietin (EPO) ELISA Kit
Supplier: Bioss
The microtiter plate provided in this kit has been pre-coated with an antibody specific to EPO. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific to EPO. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After the TMB substrate solution is added, only those wells that contain EPO, biotin-conjugated antibody, and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution, and the color change is measured spectrophotometrically at a wavelength of 450 nm ±10 nm. The concentration of EPO in the samples is then determined by comparing the O.D. of the samples to the standard curve.
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Anti-EPHB2 Rabbit Polyclonal Antibody
Supplier: ProSci Inc.
EphrinB proteins are thought to play key roles in cellular functions as diverse as neuronal migration and blood vessel development (Flanagan and Vancerhaeghen, 1998; Dufour et al., 2003; Oike et al., 2002). EphrinB molecules expressed at the membrane surface bind to the EphB family receptors on target cells during cellto cell contact. This interaction leads to cell signaling in the target cell but also generates a reverse signal in the cell expressing EphrinB on its surface. This reverse signaling event is thought to be critical for vessel maturation and neuronal development. Importantly, tyrosine phosphorylation of EphrinB is thought to be a critical component of this reverse signaling event (Palmer et al., 2002). Recent work suggests that phosphorylation of a specific EphrinB residue (Tyr298) plays a key role in EphrinB signaling (Kalo, et al., 2001).
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Supelco® Discovery® BIO Reversed-Phase Solution to Protein and Peptide Separation Challenges
Supplier: Merck
Discovery® BIO Wide Pore reversed-phase columns satisfy the need for efficiency, selectivity, scalability, and reproducibility for RP HPLC analyses of proteins, peptides, and small biomolecules.
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Protein stabilising cocktail, Pierce™
Supplier: Thermo Fisher Scientific
The Protein Stabilising Cocktail is a versatile stabilising solution that increases the shelf-life of purified or partially purified proteins during routine storage.
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Supelco® BIOshell™ HPLC Columns, 400 Å Protein C4 Fused-Core®
Supplier: Merck
BIOshell™ 400 Å Protein C4 columns contain 3,4 µm advanced Fused-Core® particles with 400 Å pores that are specifically engineered to provide efficient separation of large proteins.
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Anti-CD63 Mouse Monoclonal Antibody [clone: CDLA63-1]
Supplier: ProSci Inc.
CD63 functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. [UniProt].
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Anti-CD44 Mouse Monoclonal Antibody [clone: HCM15-1]
Supplier: ProSci Inc.
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). [UniProt].
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Supelco® Discovery® BIO RP18e Reversed-Phase Solution to Protein and Peptide Separation Challenges
Supplier: Merck
Discovery® BIO Wide Pore reversed-phase columns satisfy the need for efficiency, selectivity, scalability, and reproducibility for RP HPLC analyses of proteins, peptides, and small biomolecules.
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Supelco® Discovery® BIO C5 Reversed-Phase Solution to Protein and Peptide Separation Challenges
Supplier: Merck
Discovery® BIO Wide Pore reversed-phase columns satisfy the need for efficiency, selectivity, scalability, and reproducibility for RP HPLC analyses of proteins, peptides, and small biomolecules.
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Nettoyants Extran®, concentrés liquides, pour usage manuel (MA), Supelco®
Supplier: Merck
Une gamme de produits pour nettoyage manuel ou en machine, mise au point pour répondre aux besoins de nettoyage de la verrerie et des petits instruments de laboratoire.
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repliQa HiFi ToughMix
Supplier: Quantabio
Superior speed and inhibitor tolerance.
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XCORE UHPLC Columns, Silica
Supplier: ISERA
Ultra-fast separation at moderate pressure with state-of-the-art core shell technology particles in XCORE columns.
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IL-11 (Human) ELISA Kit
Supplier: Abcam
An Sandwich ELISA kit for quantifying human IL-11 in human serum, plasma & other biological fluids.
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Urothelial Cell Growth Medium
Supplier: PROVITRO
Urothelial Cell Growth Medium is a sterile, serum-free liquid culture medium designed for the cultivation of Human Urothelial Epithelial Cells (HUEPC). Delivered in the form of a basal medium, it becomes a complete and suitable environment for culturing HUEPC upon the addition of three supplement components.
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Laboratory coats, Tyvek® 500
Supplier: DuPont
DuPont™ Tyvek® 500 Labcoat with zipper, model PL309NP, offers enhanced protection for individuals exposed to hazardous substances.
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Smooth Muscle Cell Growth Medium
Supplier: PROVITRO
Smooth Muscle Cell Growth Medium is a sterile liquid culture medium designed for cultivating human smooth muscle cells (HSMC). Provided in the form of a basal medium, it is ideal for culturing HSMC upon the addition of supplement mix components.
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Dual auto-reader for steam and vaporised hydrogen peroxide 490, Attest™
Supplier: 3M MEDICAL
Auto-reader for use with 3M™ Attest™ Rapid Readout Biological Indicators and process challenge packs for steam. Includes ethernet cable for web app connectivity.
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XCORE UHPLC Columns, C18
Supplier: ISERA
Ultra-fast separation at moderate pressure with state-of-the-art core shell technology particles in XCORE columns.