12487 Results for: "Enzo Life Sciences"

Supplier: Enzo Life Sciences

Adenosine is an endogenous nucleoside generated locally in tissues under conditions of hypoxia, ischemia, or inflammation. It modulates a variety of physiological functions in many tissues including brain and heart. It exerts its action via four specific adenosine receptors (also named P1 purinergic receptors): A1 Adenosine Receptor (A1AR), A2A Adenosine Receptor (A2AAR), A2B Adenosine Receptor (A2BAR), and A3 Adenosine Receptor (A3AR). All are integral membrane proteins and members of the G Protein-Coupled Receptor superfamily. The various adenosine receptors can be distinguished on the basis of their differential selectivity for adenosine analogs. Expression of A3AR has been reported in brain, kidney, liver, and heart. It plays a role in modulation of cerebral ischemia, asthma, and cell growth. In addition, it may have a cardioprotective role for A3AR. Expression of A3AR was reported to be elevated in cancerous tissues as well as in auto-immune inflammatory diseases.

Supplier: Enzo Life Sciences

Major metabolite of zolpidem.

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

Prostanoid receptor ligand.

Supplier: Enzo Life Sciences

Biosynthesis in endothelial cells. Induces vasodilation, inhibits platelet aggregation by receptor-mediated stimulation of adenylate cyclase. Cytoprotective. Fibrinolytic. Half-life under physiological conditions is 2 minutes.

Supplier: Enzo Life Sciences

PKC activator

Supplier: Enzo Life Sciences

PDE inhibitor

Supplier: Enzo Life Sciences

Vitronectin is a plasma glycoprotein that circulates in the blood as a mixture of both 75kDa and 65kDa forms. Vitronectin is a major cell adhesive glycoprotein, and a common component of extracellular matrix and plasma. It competes effectively with other plasma proteins, and often participates in cell attachment, regulation of blood coagulation and immune responses. It has similar tissue distribution to fibronectin, which is recognized by its integrin receptor.

Supplier: Enzo Life Sciences

Human cytochrome P-450 (CYP2A6), the ortholog of rat CYP2A3 is principally found in the liver, but recently interest in its localization in the nasal mucosa has grown due to its role in the metabolism of inhaled xenobiotics and nicotine.

Supplier: Enzo Life Sciences

The caspases are a family of cysteine proteases that cleave after certain aspartate residues, and are primarily recognized as mediators of apoptosis. caspases are synthesized as inactive zymogens that can be cleaved to form active enzymes following the induction of apoptosis by stress or death receptors. Initiator caspases (e.g. caspase-8 and -10) are activated by dimerization of the zymogen on a dedicated adaptor protein. These activated initiator caspases in-turn cleave downstream effector or executioner caspases (e.g. caspase-3, -6, and -7) in a cascade-like manner, which cleave key cellular proteins that lead to the morphological changes associated with apoptotic cell death.

Supplier: Enzo Life Sciences

TRAIL is a type II membrane protein and expressed in a variety of human tissues.

Supplier: Enzo Life Sciences

TLR4 activator.

Supplier: Enzo Life Sciences

The thymidine analogue BrdU (5-Bromo-2-Deoxyuridine), a derivative of uridine, can substitute for thymidine during DNA synthesis.

Supplier: Enzo Life Sciences

Cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC50=14µM) by binding to the mitotic kinesin Eg5.

Supplier: Enzo Life Sciences

HDAC inhibitor

Supplier: Enzo Life Sciences

GABA_A receptor antagonist.

Supplier: Enzo Life Sciences

TLR4 activator.

Supplier: Enzo Life Sciences

Sub-nanomolar potent, non-competitive mGlu1 antagonist (Ki=0.34nM). Inhibits glutamate-induced Ca2+ response at the human mGluR1 (IC50=0.55nM). Selective over mGluR5 (>400-fold). Displays no activity at mGluR2, mGluR3, mGluR4, mGluR6, AMPA or NMDA receptors (IC50>10µM). Centrally active following systemic administration.

Supplier: Enzo Life Sciences

M2 receptor modulator.

Supplier: Enzo Life Sciences

mGluR5 antagonist.

Supplier: Enzo Life Sciences

For the quantitative determination of human Cytochrome c in cell lysates

Supplier: Enzo Life Sciences

For the quantitative determination of human Osteopontin in culture supernatants, milk, plasma, and urine. Cited sample type includes serum.

Supplier: Enzo Life Sciences

Calmodulin inhibitor

Supplier: Enzo Life Sciences

TRPA1 activator.

Supplier: Enzo Life Sciences

Human DNA fragmentation fragment (DFF) 45 and its mouse homologue caspase activated deoxyribonuclease (ICAD) are the inhibitors of DFF40 and CAD, respectively.

Supplier: Enzo Life Sciences

Inhibits mitochondrial ATPases (F₁F₀). Stimulates lysosome acidification due to shunting of membrane potential. Induces apoptosis in a variety of cell types. Induces autophagy in the IPLB-LdFB insect cell line.

Supplier: Enzo Life Sciences

MPTP activator

Supplier: Enzo Life Sciences

TLR4 activator.

Supplier: Enzo Life Sciences

cADPR antagonist.