12487 Résultats pour : "Enzo Life Sciences"

Supplier: Enzo Life Sciences

L(+)-Arginine

Supplier: Enzo Life Sciences

Inhibitor of caspase-1 and -4

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NADPH-Na4

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Bcl-2 ligand

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Copper(II) protoporphyrin IX acide libre

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TLR4 activator.

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Fas ligand

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Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins at the neuromuscular junction during development.

Supplier: Enzo Life Sciences

Glutathione, a major intracellular non-protein thiol, protects against free radical damage by providing reducing equivalents for several key antioxidant enzymes. In addition, glutathione acts as a scavenger of hydroxyl radicals and nascent oxygen. Elevated glutathione levels are associated with a reduced rate of illness, higher levels of self-rated health, lower cholesterol, lower body mass index, and lower blood pressure among the elderly. Glutathione provides a primary defense system for the removal of oxidants in the brain. Studies have revealed a correlation between low glutathione levels and damage to neurons that manufacture dopamine, suggesting a link to Parkinson's disease.

Supplier: Enzo Life Sciences

Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins during development at the neuromuscular junction. Agrin, MuSK and Rapsyn are all essential components for AChR aggregation through an unknown mechanism. The C-terminal region of agrin is released into the medium, interacts with receptors on the muscle surface, and induces AChR aggregation. The central region contains two O-linked glycosylation sites and a domain homologous to domain III of laminin. The N-terminal region anchors agrin to the extracellular matrix via other basal membrane components. This region also contains a protease inhibitor domain and glycosaminoglycan attachment sites, increasing the predicted MW from 200kDa to ~600kDa. The diagram shown indicates the domain structure and functional regions of agrin, as well as domains required for AChR aggregation and alpha-dystroglycan and heparin binding.  Various agrin isoforms are generated by alternative splicing at the X, Y and Z sites, and differ in the presence or absence of small inserts. The isoforms can determine the biological activity of agrin and their expression in specific tissues and stages of development. While no difference in functional activity has been detected between splicing variants at site X, insertion of a 4 aa peptide at site Y modestly increases agrins nAChR clustering activity. Insertion of an 8 aa peptide at splicing site Z increases the clustering activity of soluble rat agrin 10,000 fold.

Supplier: Enzo Life Sciences

Produced in E.coli.

Supplier: Enzo Life Sciences

Flavonoid. Racemic mixture. Urinary metabolite of daidzein. Inhibits 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 signalling pathway. Shows positive effects on the incidence of prostate cancer and physiological changes after menopause. Functions as a DHT blocker. Preferentially activates estrogen receptor β (ERβ).

Supplier: Enzo Life Sciences

Enzyme regulation and kinetics, comparative studies of substrate or inhibitor specificities, cleavage of target proteins. Assay or digest conditions can vary widely, but concentrations for the MMP enzymes can range between 10 and 300nM, or higher. Reaction temperatures can be between 25 and 37 °C, and reaction times can range from 10 min to overnight, again depending on application and substrate. A typical assay buffer is 50 mM HEPES, pH 7,0, 10 mM CaCl₂, 0,05% Brij-35. For more information, contact Enzo Life Sciences Technical Support.

Supplier: Enzo Life Sciences

Phosphodiesterase PDE II inhibitor, IC50=0.8 µM. Also inhibits adenosine deaminase, Ki=4 nM.

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Negative control for Int-H1-S6A F8

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Substance P antagonist

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4-Nitroaniline ≥95% (par GC)

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Host: Rabbit

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Activator of PKC and PPARα.

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A potent, irreversible inhibitor of various plant β-glucosidases and mammalian glucocerebrosidase. Has been employed in in vitro and animal models for Gaucher’s disease. It raises intracellular levels of glucosylceramide by inhibiting glucosylceramidase.

Supplier: Enzo Life Sciences

Estrogen receptor inhibitor

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Inhibits α-mannosidase. Inhibits asparagine-linked oligosaccharide processing. Immunomodulator.

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MHC ligand.

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Ultra-pure

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NF-kappaB inhibitor

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Alkaline ceramidase inhibitor

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Gabapentin-lactam but not gabapentin reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease. It opens mitochondrial ATP-dependent potassium channels.

Supplier: Enzo Life Sciences

GluR receptors are permeable to cations Na and K and Ca2+. Gating of Glu receptors by glutamate is extremely fast and therefore the Glu receptors mediate most excitatory (depolarizing) currents in the brain during basal neuronal activity.

Supplier: Enzo Life Sciences

Adenosine is an endogenous nucleoside generated locally in tissues under conditions of hypoxia, ischemia, or inflammation. It modulates a variety of physiological functions in many tissues including brain and heart. It exerts its action via four specific adenosine receptors (also named P1 purinergic receptors): A1 Adenosine Receptor (A1AR), A2A Adenosine Receptor (A2AAR), A2B Adenosine Receptor (A2BAR), and A3 Adenosine Receptor (A3AR). All are integral membrane proteins and members of the G Protein-Coupled Receptor superfamily. The various adenosine receptors can be distinguished on the basis of their differential selectivity for adenosine analogs. A1AR is widely distributed and has been well characterized. High expression of A1AR is found in brain, dorsal horn of the spinal cord, adrenal gland, and atria, and other tissues including adipose, colon, and kidney. A1AR is the most prominent adenosine receptor in adipocytes and has become a target for research on obesity. A possible role in cell proliferation and carcinogenesis has also been suggested for A1AR.

Supplier: Enzo Life Sciences

dPPA is a selective activator of PKCß. It is at least 100-fold more potent for the ß isozymes than the α, γ, δ or ε isozymes but activates the ß1 isozyme to only 60% of maximal activity. Mimics the effect of TNF on endothelial cells but does not translocate PKC.