12487 Résultats pour : "ENZO LIFE SCIENCES"

Supplier: Enzo Life Sciences

High-activity, high-purity CD40L construct for immune activation

Supplier: Enzo Life Sciences

Highly active

Supplier: Enzo Life Sciences

Produced in insect cells. Active recombinant human DPP8 with an N-terminal purification tag.

Supplier: Enzo Life Sciences

A QuantiZyme™ Assay System. The MMP-12 Fluorometric (also known as fluorimetric) Drug Discovery Kit is a complete assay system designed to screen inhibitors of matrix metalloproteinase-12 (MMP-12, metalloelastase, macrophage elastase) using a quenched fluorogenic peptide: OmniMMP™ fluorogenic substrate Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH.

Supplier: Enzo Life Sciences

Estrogen receptor α activator.

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG1

Supplier: Enzo Life Sciences

Host: Rat, Isotype: IgG2a

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG2a

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM1, CEACAM3-CEACAM8) and 11 pregnancy-specific glycoprotein (PSG1-PSG11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leukocytes. Overexpression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocytes and dendritic cell activation, receptors of Neisseria species and other bacteria.

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG2a

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG1

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG1

Supplier: Enzo Life Sciences

For the quantitative determination of soluble mouse CD14 in serum, plasma and cell culture medium.

Supplier: Enzo Life Sciences

BAP31 (B cell receptor-associated protein 31) is an integral protein of the ER membrane that forms a large hetero-oligomeric complex with the related BAP29. The cytosolic domain of BAP31 contains two identical caspase recognition sites that are preferentially cleaved by initiator caspases, including caspase-8. After activation of cell surface death receptors, human BAP31 is cleaved into a membrane-embedded fragment called p20, which induces apoptosis when expressed ectopically. The p20 fragment can mediate Ca2+-dependent apoptotic cross-talk between the ER and mitochondria, stimulating cytochrome c release. In addition to its role in apoptosis, BAP31 is a component of the ER quality control compartment and functions as a cargo receptor for ER export of transmembrane proteins such as cellubrevin, MHC class I molecules, and cytochrome P450 2C2.

Supplier: Enzo Life Sciences

Giantin, the largest Golgi membrane protein, is C-terminally anchored to cis- and medial-Golgi membranes and forms a long ~250nm coiled-coil rod that directly interacts with microtubules in a cell-cycle regulated way. It is an excellent marker for mammalian golgi complex. Giantin plays also a role in docking COPI vesicles to Golgi membranes. It is speculated that after mitosis giantin aids in guiding vesiculated Golgi membranes to the microtubule organizing center to reform a new Golgi apparatus.

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG2a

Supplier: Enzo Life Sciences

Rat RELM-α (resistin-like molecule-α/FIZZ1) is a member to the family of adipocyte-secreted proteins called adipocytokines. Both RELM-α and resistin share high sequence homology in their C-terminal signature domain. However, both resistin and RELM-α's biological function as well as its molecular target is largely unknown. Recombinant rat RELM-α is a 10.5 kDa protein consisting of 89 amino acid residues.

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG1

Supplier: Enzo Life Sciences

The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. Ten human homologs of TLRs (TLR1-10) have been described. TLR8 gene contains three exons, two of which have coding function. TLR8 cDNA codes for a protein of approximate molecular weight of 120kDa.

Supplier: Enzo Life Sciences

p300 HAT activator.

Supplier: Enzo Life Sciences

Cell permeable modulator of Ins(1,4,5)-P3-induced Ca2+ release. A prototype drug for a group of structurally related calcium channel blockers in human platelets. Has been shown, in the absence of other stimuli, to activate TRPV1, V2 and V3, but not TRPV4, V5 and V6 expressed in HEK 293 cells. Potentiates the effect of capsaicin, protons and heat on TRPV1. It was originally introduced as an IP3 receptor blocker and subsequently as an inhibitor of store-operated Ca2+ entry (75µM).

Supplier: Enzo Life Sciences

Immunization and blocking peptide for Glutamic Acid Decarboxylase (GAD) antibody (BML-GC3208).

Supplier: Enzo Life Sciences

A predominant cleaved form of pro-glucagon found in the pancreas and central nervous system. It has been reported that human pancreatic endocrine tumours contain molecular forms of GLP-1 which resemble those expressed in the small intestine, rather than in their tissue of origin. Within the CNS, GLP-1 powerfully inhibits feeding in fasting rats, an action which is blocked by prior administration of the GLP-1 receptor antagonist exendin [9-39]. This observation led to the suggestion that central GLP-1 is a physiological mediator of satiety and has projected GLP-1 into the obesity control debate. Glucagon-like peptide (GLP) 1 [1-36] also serves as a control peptide for Anti-Glucagon-like Peptide (GLP) 1 (BML-GA1176) and Anti-Glucagon-like Peptide (GLP) 1 [7-36] amide (BML-GA1178). Blocks immunoreactivity at 10 nmol per ml diluted antibody.

Supplier: Enzo Life Sciences

A number of E2s in Saccharomyces cerevisiae and their homologues have been identified. One such family of E2s is the UBC4/5, characterised as essential for the degradation of short-lived, regulatory and abnormal proteins. Protein levels of S. cerevisiae UbC4/5 are up-regulated in response to stress, and their loss results in severe effects on cellular functions. A human gene product that is 79% identical to S. cerevisiae UBC4/5 in amino-acid sequence was identified as UbcH5a. In addition, two other human members of this highly conserved E2 class were also cloned and designated as UbcH5b and UbcH5c, having 88% and 89% identity to UbcH5a, respectively. Members of the UbcH5a/b/c are the most active class of E2s in cell extracts. The importance of this enzyme class is underscored by the critical role of UBC4/5 in S. cerevisiae. UbcH5a stimulates the conjugation of ubiquitin to the tumour-repressor p53 in the presence of E6-AP and E6. Moreover, UbcH5 family is implicated in c-fos recognition, the modulation of which is controlled by the ubiquitin-proteasome pathway. UbcH5b and UbcH5c are associated with the signal-induced conjugation and subsequent degradation of IkBalpha in the presence of the SCF complexes. UbcH5c also catalyses the ubiquitination leading to the processing of p105 precursor to form p50, a subunit of the heterodimeric transcription factor NF-kB. The range and diversity of substrates and E3s with which this class of E2 enzymes interact, suggest their complex roles in cellular functions require to be studied further.

Supplier: Enzo Life Sciences

GST-S5a (human Rpn10) is covalently coupled to agarose at a concentration of 0,5 mg protein/ml of settled resin.

Supplier: Enzo Life Sciences

Recombinant full length DnaK produced in E. coli.

Supplier: Enzo Life Sciences

Inhibitor of PARG and eNOS