49512 Résultats pour : "Alsto"

Supplier: Biosensis

The Lamin proteins are members of the intermediate filament protein family but are located inside the nucleus rather than in the cytoplasm (1). The lamins function as skeletal components tightly associated with the inner nuclear membrane. Originally the proteins of the nuclear cytoskeleton were named Lamin A, B and C, from top to bottom as visualized on SDS-PAGE gels. Subsequently it was found that Lamins A and C were coded for by a single gene (2), while the Lamin B band may contain two proteins encoded by two genes now called Lamin B1 and Lamin B2. Lamin A has a mass of about 74kDa while Lamin C is 65kDa. The Lamin A protein includes 98 amino acids missing from Lamin C, while Lamin C has a C-terminal 6 amino acid peptide not present in Lamin A. Apart from these regions Lamin A and C are identical so that antibodies raised against either protein are likely to cross react with the other, as is the case with this monoclonal. Lamin polymerization and depolymerization is regulated by phosphorylation by cyclin dependent protein kinase 1 (CDK1), the key component of "maturation promoting factor", the central regulator of cell division. Activity of this kinase increases during cell division and is responsible for the breakdown of the nuclear lamina. Mutations in the LMNA gene are associated with several serious human diseases, including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease type 2B1, and Hutchinson-Gilford progeria syndrome. This family of diseases belong to a larger group which are often referred to as Laminopathies, though some laminopathies are associated in defects in Lamin B1, B2 or one or other of the numerous nuclear lamina binding proteins. A truncated version of lamin A, commonly known as progerin, causes Hutchinson-Gilford progeria syndrome, a form of premature aging (3).

Supplier: Cytiva

MicroSpin™ columns are designed for the rapid purification of DNA in conjunction with Sephadex™ G-25 DNA grade for use in a wide range of applications, including desalting, buffer exchange and removal of unincorporated nucleotides from end-labelled oligonucleotides.

Supplier: Cytiva

Sera-Xtracta Cell-Free DNA Kit for the efficient extraction and purification of cell-free DNA (cfDNA) from plasma.

Supplier: MP Biomedicals

SPINeasy DNA kit for blood is a high-performance genomic DNA (gDNA) extraction kit based on silica-membrane spin-column technology. This kit enables quick isolation of gDNA from whole blood preserved in different anticoagulants (EDTA, Heparin and sodium citrate), typically in less than 30 minutes.

Supplier: MP Biomedicals

The MagBeads FastDNA Kit for Feces allows thorough sample lysis and quick isolation of DNA from fecal samples. It is using magnetic beads with high DNA binding capacity for extraction of high yields of pure DNA. This is done manually using a magnetic rack or adapted to automated instruments for high throughput processing.

Supplier: Thermo Fisher Scientific

Heratherm™ large capacity ovens were designed for larger samples or high sample volume. All models have a large, easy to view, vacuum fluorescence display and simple to use touch button operation which is controlled by a microprocessor and automatic over-temperature alarm system to protect samples. All units are available in convenient 230 V version - no special connection required.

Supplier: HUBER

Les thermostats à immersion forment la base de multiples combinaisons avec des récipients de bain en acier inoxydable ou en polycarbonate. Tous les modèles sont équipés d'une puissante pompe de pression/d'aspiration et sont conformes aux exigences de sécurité de classe III (FL) pour une utilisation avec des liquides inflammables. Des températures pouvant descendre jusqu'à −30 °C peuvent être obtenues en association avec un bain réfrigéré. Une pince à vis est incluse pour permettre aux thermostats d'être montés sur les récipients. Un adaptateur de pompe pour un contrôle externe de la température et des serpentins de refroidissement pour un raccordement d'eau de refroidissement sont disponibles comme accessoires en option.

Supplier: Testo

The testo 160 THL climate logger with integrated temperature, humidity, lux and UV sensors ensures comprehensive monitoring of the ambient climate and light conditions in museums at all times. The testo 160 THL belongs to the testo 160 data logger range, which was developed especially for the particular requirements in museums. Versatile options for combinations of integrated sensors and probes, any monitoring situation, from exhibitions to storage, is covered.

Supplier: Azbil Telstar Technologies

Bio II Advance Plus a été développé pour augmenter la commodité, le confort et la sécurité de l'utilisateur, l'échantillon et l'environnement, avec des dimensions réduites. Bio II Advance Plus représente le meilleur équilibre entre les dimensions externes et la zone de travail utile : 759 mm de large pour 1260 mm de hauteur seulement et fournit ainsi un volume utile de 340 dm³. Cette plage a été conçue pour offrir les meilleures caractéristiques en matière de sécurité biologique, classe II, tout en conservant une ergonomie pratique, des conditions d'utilisation silencieuses, un nettoyage aisé, une consommation énergétique moins importante et un entretien et une maintenance faciles.

Supplier: VACUUBRAND

Les groupes de pompage VACUUBRAND répondent à un large éventail d'applications pour le vide ou le transfert de gaz et de vapeurs corrosives dans des laboratoires, en tant qu'alternative aux pompes à palettes et à jet d'eau. Design compact, fonctionnement silencieux. Longue durée de vie, remplacement aisé des membranes et des clapets. Vide exempt d'huile.

Supplier: Biosensis

The amyloid beta peptide is derived from the cleavage of the Amyloid precursor protein (APP) and varies in length from 39 to 43 amino acids. However, the form(s) of amyloid-beta peptide (Aβ) associated with the pathology characteristic of Alzheimer’s disease (AD) remains unclear. In particular, the neurotoxicity of intraneuronal Aβ accumulation is an area of considerable research and controversy principally because antibodies thought to be specific for Aβ have been shown to actually detect intraneuronal APP and not Aβ exclusively. MOAB-2 (mouse IgG2b) is a pan-specific, high-titer antibody to Aβ residues 1-4 as demonstrated by biochemical and immunohistochemical analyses (IHC), and is highly specific just to amyloid beta peptide. MOAB-2 did not detect APP or APP-CTFs in cell culture media/lysates (HEK-APPSwe or HEK APPSwe/BACE1) or in brain homogenates from transgenic mice expressing 5 familial AD (FAD) mutation (5xFAD mice). Using IHC on 5xFAD brain tissue, MOAB-2 immunoreactivity co-localized with C-terminal antibodies specific for Aβ40 and Aβ42. MOAB-2 did not co-localize with either N- or C-terminal antibodies to APP. In addition, no MOAB-2-immunreactivity was observed in the brains of 5xFAD/BACE-/- mice, although significant amounts of APP were detected by N- and C-terminal antibodies to APP, as well as by 6E10. In both 5xFAD and 3xTg mouse brain tissue, MOAB-2 co-localized with cathepsin-D, a marker for acidic organelles, further evidence for intraneuronal Aβ, distinct from Aβ associated with the cell membrane. MOAB-2 demonstrated strong intraneuronal and extra-cellular immunoreactivity in 5xFAD and 3xTg mouse brain tissues.

Supplier: G-Biosciences

G-Biosciences offers a wide selection of genomic isolation kits that purify high quality genomic DNA from a variety of sources and for a wide array of applications. G-Biosciences XIT™ DNA kits produce protein-free, high quality DNA through the principle of cell lysis, protein digestion and precipitation and genomic DNA purification. No chloroform or phenol extraction is required. High quality DNA can be isolated from sample types including: animal tissues, cells, whole blood, bacteria, buccal cells, plant tissues, mouse tail, yeast and FFPE tissue. G-Biosciences XIT™ DNA kit procedures remove contaminants and enzyme inhibitors allowing the purified DNA to be ready for immediate use for all downstream analyses. The purified DNA from G-Biosciences XIT™ DNA kits have a A₂₆₀/A₂₈₀ ratio between 1,7 and 1,9 (with the exception of the buccal cells kit with a ratio between 1,8 and 2,0) and are up to 200 kb in size.