Human Recombinant CD19 (from Cells)

50 µG

N° de catalogue PRSI91-513

Fournisseur: ProSci Inc.

N° de catalogue PRSI91-513

Fournisseur: ProSci Inc.

Numéro CAS:

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Spécifications

Numéro CAS:

Prix

SFr. 589.00

Connexion Pour la disponibilité

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Product Details & Documents

CD19 is a single-pass type I membrane protein containing 2 Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. CD19 primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Src-family kinases and recruitment of PI-3 kinase. CD19 Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) which is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen.

This recombinant protein can be used for biological assays. For research use only.

Fusion-Tag: C-Fc tag

Documents

Fiche technique

75789-702.pdf

About ProSci

Spécifications

Cdt:
50 µG
Purity:
> 95% as determined by reducing SDS-PAGE
Synonyme de protéine:
B-Lymphocyte Antigen CD19|T-Cell Surface Antigen Leu-12|Differentiation Antigen CD19|CD19|B-Lymphocyte Surface Antigen B4
Masse moléculaire:
57.3 kD
Sequence:
Pro20-Lys291
Source:
Cells
Cat. No.:
PRSI91-513
Conditions de stockage:
Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
Formulation:
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.2. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Tag sequence:
C-Fc tag
Tested applications:
Bioassay
Species:
Human
Nom de la protéine/du peptide:
CD19
Type de protéine/peptide:
Recombinant