Mouse CXCL5 ELISA Kit is a sandwich ELISA kit for the quantitative detection for mouse chemokine (C-X-C motif) ligand 5 (CXCL5, ENA-78).

• No detectable cross-reactivity with other relevant proteins

CXCL5 is a small cytokine belonging to the CXC chemokine family that is also known as epithelial-derived neutrophil activating peptide 78 (ENA-78). It is produced following stimulation of cells with the inflammatory cytokines interleukin-1 or tumour necrosis factor-alpha. Expression of CXCL5 has also been observed in eosinophils, and can be inhibited with the type II interferon IFN-Gamma. This chemokine stimulates the chemotaxis of neutrophils possessing angiogenic properties. It elicits these effects by interacting with the cell surface chemokine receptor CXCR2. The gene for CXCL5 is encoded on four exons and is located on human chromosome 4 amongst several other CXC chemokine genes. CXCL5 has been implicated in connective tissue remodeling. CXCL5 plays a role in reducing sensitivity to sunburn pain in some subjects, and is a potential target which can be utilised to understand more about pain in other inflammatory conditions like arthritis and cystitis.