Human GDF-15 ELISA Kit is a sandwich ELISA kit for the quantitative detection for human growth differentiation factor 15 (GDF-15).

• No detectable cross-reactivity with other relevant proteins

GDF-15, also known as TGF-PL, MIC-1, PDF, PLAB, and PTGFB, is a protein belonging to the transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. Using FISH, the MIC1 gene is mapped to 19p13.2-p13.1. Its expression in liver can be significantly up-regulated in during injury of organs such as liver, kidney, heart and lung. GDF15 showed increased expression and secretion during erythroblast maturation. GDF-15 functions as an anti-inflammatory cytokine by directly interfering with chemokine signaling and integrin activation.