Human OSM ELISA Kit for the quantitative detection for human Oncostatin M.

• No detectable cross-reactivity with other relevant proteins

Oncostatin M is a protein that in humans is encoded by the OSM gene. OSM is a pleiotropic cytokine that belongs to the interleukin 6 group of cytokines. The OSM gene is mapped on 22q12.2. Of these cytokines it most closely resembles leukemia inhibitory factorLIF in both structure and function. Treatment with recombinant OSM leads to the inhibition of proliferation and changes in cellular morphology of a number of tumor cell lines derived from a wide variety of tissue types. OSM signals through cell surface receptors that contain the protein gp 130. The type I receptor is composed of gp 130 and LIFR, the type II receptor is composed of gp 130 and OSMR.