42864 Results for: "ProSci Inc."

Supplier: ProSci Inc.

Anti-Hepatitis C Mouse Monoclonal Antibody

Supplier: ProSci Inc.

Anti-Hepatitis C Mouse Monoclonal Antibody

Supplier: ProSci Inc.

Anti-Hepatitis C Mouse Monoclonal Antibody

Supplier: ProSci Inc.

Anti-Hepatitis C Mouse Monoclonal Antibody

Supplier: ProSci Inc.

Anti-MKI67 Rabbit Polyclonal Antibody

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Anti-COPS5 Rabbit Polyclonal Antibody

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Anti-TNFRSF10B Rabbit Polyclonal Antibody

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Anti-ST14 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin.

Supplier: ProSci Inc.

General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase.

Supplier: ProSci Inc.

Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.

Supplier: ProSci Inc.

CREB1 is a transcription factor that is a member of the bZIP family of DNA binding proteins. It binds as a homodimer to the CRE (cAMP-Responsive Element), an octameric palindrome containing a conserved core sequence, 5-prime-TGACG-3-prime. It consists of two transcript variants encoding respective isoforms produced by alternate splicing. It is mapped to 2q32.3-q34. It is phosphorylated by several protein kinases and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. CREB1 is crucial for the consolidation of long-term conditioned fear memories, but not for encoding, storage, or retrieval of these memories. It is required for the stability of reactivated or retrieved conditioned fear memories.

Supplier: ProSci Inc.

Anti-CXCR7 Rabbit Polyclonal Antibody

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Anti-SIRT1 Mouse Monoclonal Antibody

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Anti-EPCAM Mouse Monoclonal Antibody

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Anti-PRNP Mouse Monoclonal Antibody

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Anti-HAMP Mouse Monoclonal Antibody

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Anti-ARHGEF11 Mouse Monoclonal Antibody

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Anti-ACTG2 Rabbit Polyclonal Antibody

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Anti-CHGA Mouse Monoclonal Antibody

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Anti-TF Mouse Monoclonal Antibody

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Anti-SIK1 Mouse Monoclonal Antibody

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Anti-C9 Rabbit Polyclonal Antibody

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FKHR belongs to the forkhead family of transcription factors, which are characterized by a distinct forkhead domain. It may play a role in myogenic growth and differentiation. The mammalian DAF-16-like transcription factors, FKHR, FKHRL1, and AFX, function as key regulators of insulin signaling, cell cycle progression, and apoptosis downstream of phosphoinositide 3-kinase. Gene activation through binding to insulin response sequences has been essential for mediating these functions. D-type Cyclins (in Class III) is required for FKHR mediated inhibition of cell cycle progression and transformation. FKHR gene is mapped to chromosome 13q14

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Anti-STMN1 Rabbit Polyclonal Antibody

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Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.

Supplier: ProSci Inc.

Inhibits the activity of dimeric NF-κ-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription.

Supplier: ProSci Inc.

Anti-DNASE1 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.

Supplier: ProSci Inc.

Anti-FBXW7 Rabbit Polyclonal Antibody