Supplier: Enzo Life Sciences

Antitumor antibiotic. DNA crosslinking and damaging agent. Inhibitor of DNA synthesis, nuclear division and cancer cells. DNA intercalating agent. Induces apoptosis in a variety of cells via a p53-dependent pathway.

Supplier: Enzo Life Sciences

Inhibits protein synthesis and induces apoptosis.

Supplier: Enzo Life Sciences

Most sensitive (0,043pmol/m) and complete colorimetric kit for intra- and extracellular cGMP quantification.

Supplier: Enzo Life Sciences

Beneficial effects in cardiovascular diseases and inflammation.

Supplier: Enzo Life Sciences

L-NIO is approximately 5 times more potent as an inhibitor of endothelial cell NO synthase than other arginine analogs such as L-NAME and L-NMMA. It inhibits NO production in endothelial cytosol (IC50=0.5µM), inhibits acetylcholine induced relaxation of rat aorta rings (IC50=2µM) and causes a dose-dependent increase in mean arterial blood pressure (EC50=19.5 mg/kg) in the rat. The product is not sterile.

Supplier: Enzo Life Sciences

Most comprehensive portfolio of heat shock protein (chaperone) products commercially available.

Supplier: Enzo Life Sciences

Most comprehensive portfolio of heat shock protein (chaperone) products commercially available.

Supplier: Enzo Life Sciences

The PGF2α high sensitivity EIA kit for the quantitative determination of PGF2α in culture supernatants, milk, plasma, serum, saliva, and urine from any species.

Supplier: Enzo Life Sciences

Cytochrome p450 is a highly conserved and diverse family of heme-containing proteins that function in the metabolism of numerous endogenous and exogenous substrates.

Supplier: Enzo Life Sciences

DNA synthesis inhibitor

Supplier: Enzo Life Sciences

Selective ligand for toll-like receptor 7 (TLR7) via IFN.

Supplier: Enzo Life Sciences

The liquid cell lysis buffer composes of 20 mM TRIS, pH 7,4, containing 500 mM sodium chloride, 10 mM EDTA, 1% Triton X-100, 20 mM sodium fluoride, 20 mM beta-glycerophosphate.

Supplier: Enzo Life Sciences

For the quantitative determination of TXB2 in culture supernatants, plasma, serum, saliva, and urine from any species. Cited sample types include cell lysate, coronary effluent, liver perfusate, platelets, rectal dialysate, and whole blood.

Supplier: Enzo Life Sciences

Adrenergic receptor ligand.

Supplier: Enzo Life Sciences

Produced in E. coli.

Supplier: Enzo Life Sciences

Sterile, double distilled endotoxin-free water for use with TLRgrade™ or endotoxin-free grade reagents.

Supplier: Enzo Life Sciences

Nicotinic acetylcholine receptor ligand.

Supplier: Enzo Life Sciences

Adrenergic receptor ligand.

Supplier: Enzo Life Sciences

The caspases are a family of cysteine proteases that cleave after certain aspartate residues, and are primarily recognized as mediators of apoptosis. caspases are synthesized as inactive zymogens that can be cleaved to form active enzymes following the induction of apoptosis by stress or death receptors. Initiator caspases (e.g. caspase-8 and -10) are activated by dimerization of the zymogen on a dedicated adaptor protein. These activated initiator caspases in-turn cleave downstream effector or executioner caspases (e.g. caspase-3, -6, and -7) in a cascade-like manner, which cleave key cellular proteins that lead to the morphological changes associated with apoptotic cell death.

Supplier: Enzo Life Sciences

Adrenergic receptor and serotonin receptor antagonist.

Supplier: Enzo Life Sciences

Orally bioavailable 284 D-1,2,4-oxadiazole.

Supplier: Enzo Life Sciences

Necroptosis inhibitor

Supplier: Enzo Life Sciences

Cell-permeable pyrrazolopyrimidine derivative that inhibits AMP kinase (Ki=109nM in the absence of AMP) in an ATP-competitive manner. It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. Decreases food intake in mice and inhibits the effects of AICAR and metformin. It has been shown to inhibit BMP type I receptors ALK2, ALK3 and ALK6. Promotes cardiomyogenesis in mouse embryonic stem cells. Induces protective autophagy in cancer cell lines.

Supplier: Enzo Life Sciences

BML-277 is a highly selective inhibitor of Chk2 (IC50=15nM). It displays potent radioprotective activity and prevents apoptosis of human T cells subjected to ionizing radiation (EC50= 3-7.6µM). Useful tool for dissecting the role of Chk2 in cellular signaling.

Supplier: Enzo Life Sciences

Produced in CHO cells. The sequence coding for the 4 extracellular Ig-like domains of mouse LAG-3 (D1-D4) is fused to the Fc portion of mouse IgG2a (hinge-CH2-CH3).

Supplier: Enzo Life Sciences

Salubrinal ≥98% (by HPLC)

Supplier: Enzo Life Sciences

Produced in HEK 293 cells. The extracellular domain of human IL-1RAcP (aa 21-356) is fused at the C-terminus to the Fc portion of human IgG1.

Supplier: Enzo Life Sciences

Prostaglandin E2 (PGE2) is an extensively studied prostaglandin owing to its predominance in inflammation, cancer, atherosclerosis, autoimmune disease, and sepsis. Oxidation of arachidonic acid by prostaglandin synthases (COX-1 and COX-2) produces prostaglandin H2 (PGH2), which is further metabolized by PGE synthases into its major product, PGE2. PGE2 mediates autocrine and paracrine signaling by binding to G-protein coupled receptors (EP1, EP2, EP3, EP4) on the cell surface, functioning to modulate phospholipase C and adenylate cyclase activity. PGE2 has been of great interest as a therapeutic target, either by modulation of its synthesis by COX inhibitors (NSAIDS) or by modulation of its receptors by downregulation or binding antagonists. PGE2 production in a variety of tissues has been shown to modulate numerous physiological processes including natriuresis in the kidney, smooth muscle elasticity in the vasculature, and the inflammatory response to damaged tissues by monocytes and macrophages.

Supplier: Enzo Life Sciences

The mammalian PDI (Protein disulfide-isomerase) family encompasses several highly divergent proteins which are involved in the processing and maturation of secretory proteins in the endoplasmic reticulum by catalyzing the rearrangement of disulfide bonds.

Supplier: Enzo Life Sciences

SOD (Superoxide dismutase) is responsible for the elimination of cytotoxic active oxygen by catalyzing the dismutation of the superoxide radical to oxygen and hydrogen peroxide. There are three SOD isoenzymes in mammalian cells, they are: EC SOD (extracellular SOD), Cu/Zn SOD (copper and zinc-containing SOD) and Mn SOD (manganese-containing SOD).