"Enzo Life Sciences"

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Human Recombinant 14-3-3zeta (GST-tag) (from E. coli), GST Tag

Supplier: Enzo Life Sciences

Produced in E. coli. Human 14-3-3ζ is fused at the N-terminus to a GST-tag.

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Mouse recombinant follistatin

Supplier: Enzo Life Sciences

Produced in E. coli. Non-glycosylated protein, containing 289 amino acids.

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Fyn kinase substrate

Supplier: Enzo Life Sciences

This peptide, EFGTYGTLSKKK, is derived from a peptide (pF4) discovered, through phage display, to be a very good substrate for Fyn kinase.

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Anti-AGRN Mouse Monoclonal Antibody

Supplier: Enzo Life Sciences

Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins during development at the neuromuscular junction. Agrin, MuSK and Rapsyn are all essential components for AChR aggregation through an unknown mechanism. The C-terminal region of agrin is released into the medium, interacts with receptors on the muscle surface, and induces AChR aggregation. The central region contains two O-linked glycosylation sites and a domain homologous to domain III of laminin. The N-terminal region anchors agrin to the extracellular matrix via other basal membrane components. This region also contains a protease inhibitor domain and glycosaminoglycan attachment sites, increasing the predicted MW from 200kDa to ~600kDa. The diagram shown indicates the domain structure and functional regions of agrin, as well as domains required for AChR aggregation and alpha-dystroglycan and heparin binding. Various agrin isoforms are generated by alternative splicing at the X, Y and Z sites, and differ in the presence or absence of small inserts. The isoforms can determine the biological activity of agrin and their expression in specific tissues and stages of development. While no difference in functional activity has been detected between splicing variants at site X, insertion of a 4 aa peptide at site Y modestly increases agrins nAChR clustering activity. Insertion of an 8 aa peptide at splicing site Z increases the clustering activity of soluble rat agrin 10,000 fold.

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Aflatoxin B2 ≥98% (by HPLC, TLC)

Supplier: Enzo Life Sciences

Hepatotoxic and hepatocarcinogenic mycotoxin.

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Methotrexate

Supplier: Enzo Life Sciences

Methotrexate

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Bovine native Ganglioside GT1b . trisodium salt (from Brain)

Supplier: Enzo Life Sciences

Prevents neurotoxicity of glutamate on neuronal cells.

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Anti-VAMP2 Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences

Vesicle-associated membrane protein (VAMP), also known as synaptobrevin, is an 18 kDa integral membrane protein localized to the cytoplasmic surface of synaptic vesicles. Two VAMP homologs, VAMP1 and VAMP2, are differentially expressed in the nervous system. VAMP2 is found in neurons associated with autonomic, sensory and integrative functions, and in non-neuronal Langerhans islets and glomerular cells. VAMP is a component of a 20S complex implicated in vesicle docking and fusion, the formation of which involves the interaction of VAMP with syntaxin through an ATP-dependent reaction modulated by synaptotagmin, SNAP-25, alpha-SNAP, and NSF.