12486 Results for: "ENZO LIFE SCIENCES"

Supplier: Enzo Life Sciences

Highly active

Supplier: Enzo Life Sciences

Produced in insect cells. Active recombinant human DPP8 with an N-terminal purification tag.

Supplier: Enzo Life Sciences

High-activity, high-purity CD40L construct for immune activation

Supplier: Enzo Life Sciences

A QuantiZyme™ Assay System. The MMP-12 Fluorometric (also known as fluorimetric) Drug Discovery Kit is a complete assay system designed to screen inhibitors of matrix metalloproteinase-12 (MMP-12, metalloelastase, macrophage elastase) using a quenched fluorogenic peptide: OmniMMP™ fluorogenic substrate Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH.

Supplier: Enzo Life Sciences

α-Synuclein accumulates in Lewy bodies, which are intraneuronal cytoplasmic inclusions present in the brains of sporadic Parkinson's disease patients, and is implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders. α-Synuclein appears to associate with other proteins that aggregate and is found in β-amyloid plaques and neuritic tangles in Alzheimer's disease.

Supplier: Enzo Life Sciences

Boc-Leu-Arg-Arg-AMC

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG1

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

Piceatannol

Supplier: Enzo Life Sciences

Host: Sheep

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG2a

Supplier: Enzo Life Sciences

Highly specific substrate for the caspase-like peptidic activity of the 20S proteasome.

Supplier: Enzo Life Sciences

Anti-PSME11 Antibody

Supplier: Enzo Life Sciences

Human Recombinant [K48R]Ubiquitin

Supplier: Enzo Life Sciences

[(Nepsilon-biotinyl)Lys6]Ubiquitin

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

Host: Rat, Isotype: IgG2a

Supplier: Enzo Life Sciences

Host: Rat, Isotype: IgG1

Supplier: Enzo Life Sciences

Microcystins are extremely toxic compounds produced by cyanobacteria (blue-green algae), belonging to species of Microcystis, Oscillatoria, Anabaena and Nostoc. The contamination of drinking water or water of recreational areas can cause severe health problems to exposed humans and animals. Microcystins possess a cyclic heptapeptide structure of the general composition cyclo(-D-Ala-L-X-D-erythro-β-methylisoAsp-L-Y-Adda-D-iso-Glu-N-methyldehydroAla), where Adda is the unusual C20 aa 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid and X and Y are variable L-aa.

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG1

Supplier: Enzo Life Sciences

The GST Family
Glutathione S-transferases (GSTs) are a large multigen family of multifunctional enzymes, which play an important role in detoxification of potentially genotoxic chemicals, by catalyzing the conjugation of glutathione to a large number of hydrophobic and electrophilic compounds, including carcinogens. They also bind to a variety of nonsubstrate ligands. The GSTs are widely distributed in mammalian species and can be grouped into four classes, based on their biochemical, immunological and structural properties: alpha, mu, pi and theta.

GSTs are dimeric, mainly cytosolic, enzymes that have extensive ligand binding properties in addition to their catalytic role in detoxification. A separate microsomal class of GSTs exists which is quite distinct from the cytosolic GSTs, and is designated as "membrane-associated proteins in eicosanoid and glutathione metabolism" (MAPEG). The N-terminal region tends to be better conserved within classes as it includes an important part of the active site.GSTs are believed to play a role in cancer prevention, as the electrophilic compounds that are conjugated to glutathione could otherwise react with and modify cellular components such as DNA, thereby initiating carcinogenesis. On the other hand, GSTs might detoxify chemotherapeutic drugs in cancer cells, thus contributing to drug resistance.
In summary, GSTs are a group of enzymes which are centrally involved in drug metabolism and detoxification. Because of their role in detoxification, they have been implicated in drug sensitivity and resistance. They may also influence mutagenesis and carcinogenesis and thus, increased GST activity may become a useful cancer marker.
Since many GST genes are polymorphic, there has been considerable interest in determining whether particular allelic variants are also associated with an increase of risk for certain diseases.

Glutathione S-transferase-Pi
The GST-Pi class (phase II detoxification enzymes) is the most abundant of the human glutathione S-transferases family, a major group of detoxification enzymes and widely distributed in the human body.
In normal human tissues, the enzymes protect cells against reactions with glutathione and reactive oxygen species by reducing organic hydroperoxides via gluthathione peroxidase activity.
The role of GST-Pi in tumor growth and progression is less well known. It is reported to be variably expressed in breast cancer and is associated with estrogen receptor levels expressed by the tumor. Down-regulation of GST-Pi activity in a study done on a T cell line appears to favor apoptosis and inhibition of GST-Pi function induces apoptosis in rat hepatoma cells.
The importance in cancer research is clear, as GST-Pi has been implicated in protection against apoptosis and also suggested to have a role in jun kinase inhibition.
The majority of human tumor cell lines express significant amounts of class pi GST, which is why it is being investigated as a potential marker for various types of cancer. GST-Pi is thought to be associated with increased resistance to anticancer drugs. GST-Pi expression is under investigation as a prognostic indicator for resistance to chemotherapy and a marker of treatment resistance.

Supplier: Enzo Life Sciences

myo-Inositol

Supplier: Enzo Life Sciences

Greatly enhances transfection efficiency

Supplier: Enzo Life Sciences

VASP (vasodilator stimulated phosphoprotein) is a proline-rich protein substrate of cAMP- and cGMP-dependent protein kinases. Phosphorylation of VASP at Ser-157 causes a mobility shift in SDS gel electrophoresis from 46 to 50 kDa, which has been used as a convenient marker to monitor cyclic nucleotide-dependent protein kinase activity. VASP is the founding member of the Ena-VASP protein family, comprising the Drosophila protein Enabled (Ena), its mouse homologue Mena (mammalian Enabled), and mouse EVL (Ena-VASP-like protein). With these proteins VASP shares a conserved overall domain organization:
a) the conserved N-terminal Ena-VASP homology domain 1 (EVH1), which mediates binding to a proline-rich motif
b) a more divergent proline-rich central domain (which is responsible for profilin binding)
c) a conserved C-terminal EVH2 domain.

VASP is expressed in a variety of mammalian cell types and tissues. In cultured cells, VASP is associated with focal adhesions, cell-cell contacts, microfilaments, and highly dynamic membrane regions. From in vitro binding data VASP has been suggested to link profilin to zyxin, vinculin, and the Listeria spp. surface protein ActA, respectively. Functional evidence indicates that VASP is a crucial factor involved in the enhancement of actin filament formation and the actin-dependent motility of intracellular bacterial pathogens.

Supplier: Enzo Life Sciences

Water soluble and stable nitric oxide radical scavenger that shows in chemical and biological systems antagonistic action against the free nitric oxide radical (NO·). The inhibitory effects were almost 2-fold stronger than those of NMMA and NOARG. Reacts with nitric oxide in a stoichometric manner. Can be used for an improved detection of nitric oxide in activated macrophage cultures in combination with the Griess reagent. Protects against endotoxin shock.

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG1